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GSE214842 ATF6 αis required for the inflammation and survival in rheumatoid arthritis fibroblast-like synoviocytes
Contributors : L Ge ; L Wang ; Y ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo characterize transcriptome changes upon ATF6 α knockdown by the siRNA in rheumatoid arthritis fibroblast-like synoviocytes (RA FLSs)
Source: GEO: Gene Expression Omnibus - October 6, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Genetic Regulation of Liver Metabolites and Transcripts Linking to Biochemical-Clinical Parameters
Conclusion In summary, this study is the first to combine metabolomics, transcriptomics, and genome-wide association studies in a porcine model. Our results improve understanding of the genetic regulation of metabolites which link to transcripts and finally biochemical-clinical parameters. Further, high-performance profiling of metabolites as intermediate phenotypes is a potentially powerful approach to uncover how genetic variation affects metabolic and health status. Our results advance knowledge in areas of biomedical and agricultural interest and identify potential correlates of biomarkers, SNPs-metabolites, SNPs-tran...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis
In this study, we have investigated the role of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of cartilage and bone destruction and determined effects of HDAC1 inhibition on both RASF phenotype in vitro, and joint inflammation and damage in the collagen-induced arthritis (CIA) model. Expression of HDACs 1–11 messenger ribonucleic acid (mRNA) was compared between RASFs and osteoarthritic synovial fibroblast (OASFs) using quantitative polymerase chain reaction. HDAC1 expression in RASFs was inhibited using small interfering RNA (siRNA) technology to assess effects on inv...
Source: Human Molecular Genetics - September 10, 2015 Category: Genetics & Stem Cells Authors: Hawtree, S., Muthana, M., Wilkinson, J. M., Akil, M., Wilson, A. G. Tags: ORIGINAL ARTICLES Source Type: research