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Condition: Reflex Sympathetic Dystrophy
Nutrition: Chia
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Total 4 results found since Jan 2013.
Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition
In this study, we hypothesized that CAP regulates monocyte accessibility by influencing their adhesion to endothelial cells. Using RNA-seq analysis, we identified that α1,3-Fucosyltransferase 7 (FucT-VII), the enzyme required for processing selectin ligands, was significantly downregulated by α7nAChR agonist among other cell-cell adhesion genes. The α7nAChR agonist inhibited monocytic cell line U-937 binding to P-selectin and adhesion to endothelial cells. Furthermore, α7nAChR agonist selectivity was confirmed by α7nAChR knockdown assays, showing that FUT7 inhibition and adhesion attenuation by the agonist was abolish...
Source: Biochemical and Biophysical Research communications - January 1, 2022 Category: Biochemistry Authors: Chia-Hsien Wu Tsuyoshi Inoue Yasuna Nakamura Rie Uni Sho Hasegawa Hiroshi Maekawa Mai Sugahara Youichiro Wada Tetsuhiro Tanaka Masaomi Nangaku Reiko Inagi Source Type: research
