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The sympathetic/beta-adrenergic pathway mediates irisin regulation of cardiac functions in zebrafish
Comp Biochem Physiol A Mol Integr Physiol. 2021 Jun 11:111016. doi: 10.1016/j.cbpa.2021.111016. Online ahead of print.ABSTRACTIrisin is a 23 kDa myokine encoded in its precursor, fibronectin type III domain containing 5 (FNDC5). The exercise-induced increase in the expression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-α) promotes FNDC5 mRNA, followed by the proteolytic cleavage of FNDC5 to release irisin from the skeletal or cardiac muscle into blood. Irisin is abundantly expressed in skeletal and cardiac muscle and plays an important role in feeding, modulates appetite regulatory peptid...
Source: Comparative Biochemistry and Physiology. Part A, Molecular and integrative physiology. - June 14, 2021 Category: Physiology Authors: Lakshminarasimhan Sundarrajan Jithine Jayakumar Rajeswari Lynn P Weber Suraj Unniappan Source Type: research

Gβγ Independent Recruitment of G-Protein Coupled Receptor Kinase 2 Drives TNFα-Induced Cardiac Beta-Adrenergic Receptor Dysfunction.
CONCLUSIONS: TNFα-induced βAR desensitization is mediated by GRK2 and is independent of Gβγ uncovering a hitherto unknown cross-talk between TNFα and βAR function providing the underpinnings of inflammation-mediated cardiac dysfunction. PMID: 23785004 [PubMed - as supplied by publisher]
Source: Circulation - June 19, 2013 Category: Cardiology Authors: Vasudevan NT, Mohan ML, Gupta MK, Martelli EE, Hussain AK, Qin Y, Chandrasekharan UM, Young D, Feldman AM, Sen S, Dorn GW, Dicorleto PE, Naga Prasad SV Tags: Circulation Source Type: research