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Activation of ryanodine-sensitive calcium store drives pseudo-allergic dermatitis via Mas-related G protein-coupled receptor X2 in mast cells
Mast cell (MC) activation is implicated in the pathogenesis of multiple immunodysregulatory skin disorders. Activation of an IgE-independent pseudo-allergic route has been recently found to be mainly mediated via Mas-Related G protein-coupled receptor X2 (MRGPRX2). Ryanodine receptor (RYR) regulates intracellular calcium liberation. Calcium mobilization is critical in the regulation of MC functional programs. However, the role of RYR in MRGPRX2-mediated pseudo-allergic skin reaction has not been fully addressed. To study the role of RYR in vivo, we established a murine skin pseudo-allergic reaction model. RYR inhibitor att...
Source: Frontiers in Immunology - June 19, 2023 Category: Allergy & Immunology Source Type: research

Modulation of NR1 receptor by CaMKII α plays an important role in chronic itch development in mice.
Modulation of NR1 receptor by CaMKIIα plays an important role in chronic itch development in mice. Brain Res Bull. 2020 Feb 26;: Authors: Li NQ, Tang Y, Huang ST, Liu XT, Zeng LP, Li H, Wan L Abstract Intractable scratching is the characteristic of chronic itch, which represents a great challenge in clinical practice. However, the mechanism underlying chronic itch development is largely unknown. In the present study, we investigated the role of NMDA receptor in acute itch and in development of chronic itch. A mouse model was developed by painting DNFB to induce allergic contact dermatitis (ACD). We f...
Source: Brain Research Bulletin - February 25, 2020 Category: Neurology Authors: Li NQ, Tang Y, Huang ST, Liu XT, Zeng LP, Li H, Wan L Tags: Brain Res Bull Source Type: research