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Specialty: Biomedical Science
Condition: Pheochromocytoma
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Total 1 results found since Jan 2013.
HIF-1α Activation by Intermittent Hypoxia Requires NADPH Oxidase Stimulation by Xanthine Oxidase
by Jayasri Nanduri, Damodara Reddy Vaddi, Shakil A. Khan, Ning Wang, Vladislav Makarenko, Gregg L. Semenza, Nanduri R. Prabhakar
Hypoxia-inducible factor 1 (HIF-1) mediates many of the systemic and cellular responses to intermittent hypoxia (IH), which is an experimental model that simulates O2 saturation profiles occurring with recurrent apnea. IH-evoked HIF-1α synthesis and stability are due to increased reactive oxygen species (ROS) generated by NADPH oxidases, especially Nox2. However, the mechanisms by which IH activates Nox2 are not known. We recently reported that IH activates xanthine oxidase (XO) and the resulti...
Source: PLoS One - March 9, 2015 Category: Biomedical Science Authors: Jayasri Nanduri et al. Source Type: research
