Filtered By:
Condition: Pheochromocytoma

This page shows you your search results in order of date.

Order by Relevance | Date

Total 31 results found since Jan 2013.

NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells
ConclusionOur findings suggest that NQO1 participates in the pathology of AD by regulating the expression and alternative splicing of the genes involved in apoptosis. These results extend our understanding of NQO1 in apoptotic pathways at the posttranscriptional level in AD.
Source: Brain and Behavior - April 1, 2023 Category: Neurology Authors: Yingshi Du, Gejing Liu, Dong Chen, Jinggang Yang, Jing Wang, Yue Sun, Qian Zhang, Yongming Liu Tags: ORIGINAL ARTICLE Source Type: research

SIRT1 exerts anti-hypertensive effect via FOXO1 activation in the rostral ventrolateral medulla
Free Radic Biol Med. 2022 Jun 7:S0891-5849(22)00223-4. doi: 10.1016/j.freeradbiomed.2022.06.003. Online ahead of print.ABSTRACTThe rostral ventrolateral medulla (RVLM) is a pivotal region in the central regulation of blood pressure (BP). It has been documented that silent information regulator 2 homolog 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent multifunctional transcription regulatory factor, has many cardiovascular protective effects. However, the role and significance of SIRT1 in the central regulation of cardiovascular activity, especially in RVLM, remains unknown. Therefore, the aim of this study ...
Source: Free Radical Biology and Medicine - June 10, 2022 Category: Biology Authors: Chang-Zhen Ren Zhao-Tang Wu Wen Wang Xing Tan Ya-Hong Yang Yang-Kai Wang Miao-Ling Li Wei-Zhong Wang Source Type: research

The Neuroprotective Effect of GM-1 Ganglioside on the Amyloid-Beta-Induced Oxidative Stress in PC-12 Cells Mediated by Nrf-2/ARE Signaling Pathway
We reported herein that GM-1 could activate Nrf-2 in the PC-12 cells co-treated with Aβ25-35, following with the activated expression of antioxidant response elements (ARE)-mediated antioxidant and detoxifying genes. Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Aβ-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway. Collectively, GM-1 could alleviate Aβ25-35-induced oxidative damage mediated through the Nrf-2/ARE signaling pathway, which might be a potential agent for AD treatment.PMID:35635605 | DOI:1...
Source: Neurochemical Research - May 31, 2022 Category: Neuroscience Authors: Xiaonan Wang Bei Li Xiaohong Yu Ye Zhou Yue Gao Source Type: research

Mass Spectrometry Imaging Identifies Metabolic Patterns Associated with Malignant Potential in Pheochromocytoma and Paraganglioma
CONCLUSIONS: The present study has identified distinct tissue metabolomic profiles of PPGLs in relation to tumor genotypes. In addition, we revealed significantly altered metabolites in the kynurenine pathway in metastatic PPGLs, which can aid in the prediction of its malignant potential. However, further validation studies will be required to confirm our findings.PMID:33983135 | DOI:10.1530/EJE-20-1407
Source: European Journal of Endocrinology - May 13, 2021 Category: Endocrinology Authors: Masanori Murakami Na Sun Christian Greunke Annette Feuchtinger Stefan Kircher Timo Deutschbein Thomas Papathomas Nicole Bechmann Paal William Wallace Mirko Peitzsch Esther Korpershoek Juliane Friemel Anne Paule Gimenez Roqueplo Mercedes Robledo Henri Jlm Source Type: research

Cancers, Vol. 12, Pages 599: Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas
Luconi Chinopoulos Patocs Pheochromocytoma/paragangliomas (Pheo/PGL) are rare endocrine cancers with strong genetic background. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) predispose patients to malignant disease with limited therapeutic options and poor prognosis. Using a host of cellular and molecular biology techniques in 2D and 3D cell culture formats we show that SDH inhibition had cell line specific biological and biochemical consequences. Based on our studies performed on PC12 (rat chromaffin cell line), Hela (human cervix epithelial cell line), and H295R (human adrenocortical cell li...
Source: Cancers - March 4, 2020 Category: Cancer & Oncology Authors: Sarkadi Meszaros Krencz Canu Krokker Zakarias Barna Sebestyen Papay Hujber Butz Darvasi Igaz Doczi Luconi Chinopoulos Patocs Tags: Article Source Type: research

Protective Effect of Mitogen- and Stress-Activated Protein Kinase on the Rats with Focal Ischemia-Reperfusion Injury
In conclusion, MSK exerted a protective effect on rat with focal ischemia-reperfusion injury through its anti-apoptotic effect on neurons and anti-inflammatory effect on astrocytes.
Source: Inflammation - November 14, 2019 Category: Allergy & Immunology Source Type: research

Autophagy impairment contributes to PBDE-47-induced developmental neurotoxicity and its relationship with apoptosis
Conclusion: Our data suggest that autophagy impairment facilitates apoptosis, which, in turn, disrupts autophagy, ultimately resulting in cell death, and that autophagy may act as a promising therapeutic target for PBDE-47-induced developmental neurotoxicity.
Source: Theranostics - June 13, 2019 Category: Molecular Biology Authors: Pei Li, Rulin Ma, Lixin Dong, Luming Liu, Guoyu Zhou, Zhiyuan Tian, Qian Zhao, Tao Xia, Shun Zhang, Aiguo Wang Tags: Research Paper Source Type: research

Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target
ConclusionWe have demonstrated for the first time that PDK1 is overexpressed in human malignant PCC and plays an important role in the malignant biological behaviors of PC12 cell. Specifically, we have revealed that knockdown of PDK1 could attenuate activation of the Akt signaling. These data suggest that PDK1 could be a new promising potential therapeutic target in human cancer treatment for malignant PCC.
Source: Clinical and Translational Oncology - February 13, 2019 Category: Cancer & Oncology Source Type: research

Oxidant-induced increase in norepinephrine secretion from PC12  cells is dependent on TRPM8 channel-mediated intracellular calcium elevation.
In this study, we show that cold-sensitive receptor TRPM8 is activated by pro-oxidant tert-butyl hydroperoxide (tBHP). Polymerase chain reaction, Western immunoblotting, and immunofluorescence indicated that TRPM8 channels are expressed in rat pheochromocytoma 12 (PC12) cells, a phenotypic model of sympathetic neurosecretion when differentiated with nerve growth factor. WS-12, a selective TRPM8 channel agonist, and tBHP increased intracellular Ca2+ concentration in differentiated PC12 cells; an effect attenuated by AMTB, a selective TRPM8 channel blocker, and siRNA-mediated TRPM8 knockdown. Blockade of TRPM8 channels als...
Source: Biochemical and Biophysical Research communications - October 27, 2018 Category: Biochemistry Authors: Peixoto-Neves D, Soni H, Adebiyi A Tags: Biochem Biophys Res Commun Source Type: research

Role of LncRNA MALAT-1 in hypoxia-induced PC12 cell injury via regulating p38MAPK signaling pathway
Conclusion MALAT-1 can promote the apoptosis and oxidative stress of PC12 cells by activating p38MAPK pathway, thus aggravating the damage of PC12 cells induced by chemical hypoxia.
Source: Neuroscience Letters - February 21, 2018 Category: Neuroscience Source Type: research

Enhanced wild-type p53 expression by small activating RNA dsP53-285 induces cell cycle arrest and apoptosis in pheochromocytoma cell line PC12.
Authors: Lin D, Meng L, Xu F, Lian J, Xu Y, Xie X, Wang X, He H, Wang C, Zhu Y Abstract Malignant pheochromocytoma (PHEO) is diagnosed only when metastasis has occurred, making it less likely for patients to obtain the benefits of traditional chemotherapy. Anti-oncogene TP53 mutation has been detected in PHEO and is possibly related to disease progression. However, whether the upregulation of wild-type TP53 has antitumoral effects on PHEO remains completely unknown. In the present study, we used RNA activation (RNAa) technique to upregulate the expression of wild-type TP53 by transfecting synthetic dsP53‑285 into...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression
In this study, we demonstrate, through an ELISA-based activity assay, that Rac1 and Cdc42 activities decrease in human pheochromocytomas (PCCs) compared with the matched adjacent non-tumor tissue. Furthermore, through quantitative mass spectrometry (MS) approaches, we show that the expression of two RHO-GEF proteins, namely ARHGEF1 and FARP1, is significantly reduced in tumors compared with matched non-tumor tissue, whereas ARHGAP36 expression is increased. Moreover, siRNA-based knockdown of ARHGEF1 and FARP1 in PC12 cells leads to a significant inhibition of Rac1 and Cdc42 activities, respectively. Finally, a principal co...
Source: Endocrine-Related Cancer - May 17, 2016 Category: Endocrinology Authors: Croise, P., Houy, S., Gand, M., Lanoix, J., Calco, V., Toth, P., Brunaud, L., Lomazzi, S., Paramithiotis, E., Chelsky, D., Ory, S., Gasman, S. Tags: Research Source Type: research