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Oxidant-induced increase in norepinephrine secretion from PC12  cells is dependent on TRPM8 channel-mediated intracellular calcium elevation.
In this study, we show that cold-sensitive receptor TRPM8 is activated by pro-oxidant tert-butyl hydroperoxide (tBHP). Polymerase chain reaction, Western immunoblotting, and immunofluorescence indicated that TRPM8 channels are expressed in rat pheochromocytoma 12 (PC12) cells, a phenotypic model of sympathetic neurosecretion when differentiated with nerve growth factor. WS-12, a selective TRPM8 channel agonist, and tBHP increased intracellular Ca2+ concentration in differentiated PC12 cells; an effect attenuated by AMTB, a selective TRPM8 channel blocker, and siRNA-mediated TRPM8 knockdown. Blockade of TRPM8 channels als...
Source: Biochemical and Biophysical Research communications - October 27, 2018 Category: Biochemistry Authors: Peixoto-Neves D, Soni H, Adebiyi A Tags: Biochem Biophys Res Commun Source Type: research

Spatiotemporal expression of KHSRP modulates Schwann cells and neuronal differentiation after sciatic nerve injury.
In conclusion, we speculated that KHSRP was involved in SCs and neuronal differentiation by inducing β-catenin mRNA decay. PMID: 24368152 [PubMed - as supplied by publisher]
Source: The International Journal of Biochemistry and Cell Biology - December 21, 2013 Category: Biochemistry Authors: Zhu X, Yao L, Yang X, Sun H, Guo A, Li A, Yang H Tags: Int J Biochem Cell Biol Source Type: research