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NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimer's disease in PC12 cells
ConclusionOur findings suggest that NQO1 participates in the pathology of AD by regulating the expression and alternative splicing of the genes involved in apoptosis. These results extend our understanding of NQO1 in apoptotic pathways at the posttranscriptional level in AD.
Source: Brain and Behavior - April 1, 2023 Category: Neurology Authors: Yingshi Du, Gejing Liu, Dong Chen, Jinggang Yang, Jing Wang, Yue Sun, Qian Zhang, Yongming Liu Tags: ORIGINAL ARTICLE Source Type: research

The Neuroprotective Effect of GM-1 Ganglioside on the Amyloid-Beta-Induced Oxidative Stress in PC-12 Cells Mediated by Nrf-2/ARE Signaling Pathway
We reported herein that GM-1 could activate Nrf-2 in the PC-12 cells co-treated with Aβ25-35, following with the activated expression of antioxidant response elements (ARE)-mediated antioxidant and detoxifying genes. Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Aβ-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway. Collectively, GM-1 could alleviate Aβ25-35-induced oxidative damage mediated through the Nrf-2/ARE signaling pathway, which might be a potential agent for AD treatment.PMID:35635605 | DOI:1...
Source: Neurochemical Research - May 31, 2022 Category: Neuroscience Authors: Xiaonan Wang Bei Li Xiaohong Yu Ye Zhou Yue Gao Source Type: research