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Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity
J Biomed Res. 2022 May 15:1-14. doi: 10.7555/JBR.36.20210198. Online ahead of print.ABSTRACTThe present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid (GA) in diabetic peripheral neuropathy (DPN). GA significantly mitigated nerve conduction velocity (NCV) deficit and morphological abnormality and reduced high-mobility group box-1 (HMGB1) expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight. Notably, GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells. Furthermore, GA obviously reduced the...
Source: Biomed Res - May 17, 2022 Category: Research Authors: Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han Source Type: research

PTEN-Induced Putative Kinase 1 (PINK1)/Parkin-Mediated Mitophagy Protects PC12 Cells Against Cisplatin-Induced Neurotoxicity.
CONCLUSIONS PINK1/Parkin-regulated mitophagy can protect against cisplatin-related neurotoxicity, suggesting therapeutic enhancement of mitophagy as a potential intervention for cisplatin-induced peripheral neuropathies. The interference of cisplatin with autophagosome-lysosome fusion may be partly responsible for cisplatin-induced neurotoxicity. PMID: 31748499 [PubMed - in process]
Source: Medical Science Monitor - November 22, 2019 Category: Research Tags: Med Sci Monit Source Type: research

HMGB-1 as a Potential Target for the Treatment of Diabetic Retinopathy.
CONCLUSIONS As a therapeutic target, HMGB-1 can inhibit inflammation and promote RGCs survival to delay DR progress through the HMGB-1-TLR4-NF-κB signaling pathway. PMID: 26454330 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - October 14, 2015 Category: Research Tags: Med Sci Monit Source Type: research