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Specialty: Lipidology
Condition: Obesity
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Total 10 results found since Jan 2013.
Slc43a3 is a regulator of free fatty acid flux Research Articles
Adipocytes take up long chain FAs through diffusion and protein-mediated transport, whereas FA efflux is considered to occur by diffusion. To identify potential membrane proteins that are involved in regulating FA flux in adipocytes, the expression levels of 55 membrane transporters without known function were screened in subcutaneous adipose samples from obese patients before and after bariatric surgery using branched DNA methodology. Among the 33 solute carrier (SLC) transporter family members screened, the expression of 14 members showed significant changes before and after bariatric surgery. One of them, Slc43a3, incre...
Source: The Journal of Lipid Research - April 30, 2020 Category: Lipidology Authors: Hasbargen, K. B., Shen, W.-J., Zhang, Y., Hou, X., Wang, W., Shuo, Q., Bernlohr, D. A., Azhar, S., Kraemer, F. B. Tags: Research Articles Source Type: research
Ablation of Soluble Epoxide Hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo
In this study, we explore the effects of soluble epoxide hydrolase (sEH) deletion on various aspects of adipocyte-function, including programing for white vs. beige-like fat, and mitochondrial and thermogenic gene-expressions. We further hypothesize that EETs and heme-oxygenase 1 (HO-1) form a synergistic, functional module whose effects on adipocyte and vascular function is greater than the effects of sEH deletion alone. In in vitro studies, we examined the effect of sEH inhibitors on MSC-derived adipocytes. MSC-derived adipocytes exposed to AUDA, an inhibitor of sEH, exhibit an increased number of small and healthy adipo...
Source: Prostaglandins and Other Lipid Mediators - July 22, 2018 Category: Lipidology Source Type: research
Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy
Publication date: Available online 6 March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Ting Hong, Zhijuan Ge, Ran Meng, Hongdong Wang, Pengzi Zhang, Sunyinyan Tang, Jing Lu, Tianwei Gu, Dalong Zhu, Yan Bi Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine wh...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - March 7, 2018 Category: Lipidology Source Type: research
Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux
Publication date: Available online 23 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Sapir Bechor, Dikla Nachmias, Natalie Elia, Yulia Haim, Maayan Vatarescu, Alicia Leikin-Frenkel, Martin Gericke, Tanya Tarnovsky, Guy Las, Assaf Rudich Obesity promotes the biogenesis of adipose tissue (AT) foam cells (FC), which contribute to AT insulin resistance. Autophagy, an evolutionarily-conserved house-keeping process, was implicated in cellular lipid handling by either feeding and/or degrading lipid-droplets (LDs). We hypothesized that beyond phagocytosis of dead adipocytes,...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - June 24, 2017 Category: Lipidology Source Type: research
miR-146a-5p inhibits TNF-{alpha}-induced adipogenesis via targeting insulin receptor in primary porcine adipocytes Research Articles
TNF-α is a multifunctional cytokine participating in immune disorders, inflammation, and tumor development with regulatory effects on energy metabolism. Our work focused on the function of TNF-α in adipogenesis of primary porcine adipocytes. TNF-α could suppress the insulin receptor (IR) at the mRNA and protein levels. Microarray analysis of TNF-α-treated porcine adipocytes was used to screen out 29 differentially expressed microRNAs (miRNAs), 13 of which were remarkably upregulated and 16 were intensely downregulated. These 29 differentially expressed miRNAs were predicted to mainly participate in ...
Source: The Journal of Lipid Research - July 31, 2016 Category: Lipidology Authors: Wu, D., Xi, Q.-Y., Cheng, X., Dong, T., Zhu, X.-T., Shu, G., Wang, L.-N., Jiang, Q.-Y., Zhang, Y.-L. Tags: Research Articles Source Type: research
Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARĪ³
Publication date: Available online 23 November 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Jinbiao Chen, Wei Wang, Yanfei Qi, Dominik Kaczorowski, Geoffrey W. McCaughan, Jennifer R. Gamble, Anthony S. Don, Xin Gao, Mathew A. Vadas, Pu Xia Sphingolipid metabolites have emerged playing important roles in the pathogenesis of nonalcoholic fatty liver disease, whereas the underlying mechanism remains largely unknown. In the present study, we provide both in vitro and in vivo evidence showing a pathogenic role of sphingosine kinase 1 (SphK1) in hepatocellular stea...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - November 25, 2015 Category: Lipidology Source Type: research
Metabolomics reveal 1-palmitoyl lysophosphatidylcholine production by peroxisome proliferator-activated receptor {alpha} Research Articles
PPARα is well known as a master regulator of lipid metabolism. PPARα activation enhances fatty acid oxidation and decreases the levels of circulating and cellular lipids in obese diabetic patients. Although PPARα target genes are widely known, little is known about the alteration of plasma and liver metabolites during PPARα activation. Here, we report that metabolome analysis-implicated upregulation of many plasma lysoGP species during bezafibrate (PPARα agonist) treatment. In particular, 1-palmitoyl lysophosphatidylcholine [LPC(16:0)] is increased by bezafibrate treatment in both plasma ...
Source: The Journal of Lipid Research - January 30, 2015 Category: Lipidology Authors: Takahashi, H., Goto, T., Yamazaki, Y., Kamakari, K., Hirata, M., Suzuki, H., Shibata, D., Nakata, R., Inoue, H., Takahashi, N., Kawada, T. Tags: Research Articles Source Type: research
Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation
Conclusions:
The LTB4-BLT signaling pathway provides a potent regulatory signal that accelerates the differentiation of mouse 3T3-L1 preadipocytes. Further investigations are necessary to confirm the exact role of LTB4 and BLTs signaling pathways in preadipocyte differentiation.
Source: Lipids in Health and Disease - August 9, 2013 Category: Lipidology Authors: Kae HirataKoichiro WadaYuka MurataAtsushi NakajimaTakashi YamashiroYoshinori Kamisaki Source Type: research
ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK Research Articles
ETC-1002 is an investigational drug currently in Phase 2 development for treatment of dyslipidemia and other cardiometabolic risk factors. In dyslipidemic subjects, ETC-1002 not only reduces plasma LDL cholesterol but also significantly attenuates levels of hsCRP, a clinical biomarker of inflammation. Anti-inflammatory properties of ETC-1002 were further investigated in primary human monocyte-derived macrophages and in in vivo models of inflammation. In cells treated with ETC-1002, increased levels of AMP-activated protein kinase (AMPK) phosphorylation coincided with reduced activity of MAP kinases and decreased production...
Source: The Journal of Lipid Research - July 10, 2013 Category: Lipidology Authors: Filippov, S., Pinkosky, S. L., Lister, R. J., Pawloski, C., Hanselman, J. C., Cramer, C. T., Srivastava, R. A. K., Hurley, T. R., Bradshaw, C. D., Spahr, M. A., Newton, R. S. Tags: Research Articles Source Type: research
Oleic acid stimulates system A amino acid transport in primary human trophoblast cells mediated by toll-like receptor 4 Research Articles
Obese women have an increased risk to deliver large babies. However, the mechanisms underlying fetal overgrowth in these pregnancies are not well understood. Obese pregnant women typically have elevated circulating lipid levels. We tested the hypothesis that fatty acids stimulate placental amino acid transport, mediated via toll-like receptor 4 (TLR4) and mammalian target of rapamycin (mTOR) signaling pathways. Circulating NEFA levels and placental TLR4 expression were assessed in women with varying prepregnancy body mass index (BMI). The effects of oleic acid on system A and system L amino acid transport, and on the activ...
Source: The Journal of Lipid Research - February 12, 2013 Category: Lipidology Authors: Lager, S., Gaccioli, F., Ramirez, V. I., Jones, H. N., Jansson, T., Powell, T. L. Tags: Research Articles Source Type: research
