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The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes
Conclusion: These results suggest a potentially important new mechanism that regulates glucose transport in podocytes and that could be injurious during diabetes.Cell Physiol Biochem 2018;51:393 –410
Source: Cellular Physiology and Biochemistry - November 19, 2018 Category: Cytology Source Type: research

Genipin Reverses HFD-Induced Liver Damage and Inhibits UCP2-Mediated Pyroptosis in Mice
Conclusion: GNP reverses HFD-induced liver damage and inhibits UCP2-mediated pyroptosis. Thus, GNP may serve as a potential therapeutic candidate for NAFLD.Cell Physiol Biochem 2018;49:1885 –1897
Source: Cellular Physiology and Biochemistry - September 20, 2018 Category: Cytology Source Type: research

Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives Human Enterocyte Differentiation
Conclusions: SLFN12 regulates human enterocytic differentiation by a pathway involving SERPB12, the deubiquitylases, and Cdx2. This pathway may be targeted to manipulate human enterocytic differentiation in mucosal atrophy, short gut or obesity.Cell Physiol Biochem 2018;48:1274 –1290
Source: Cellular Physiology and Biochemistry - July 25, 2018 Category: Cytology Source Type: research

Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF- κB/MAPK/ PI3K Signaling Systems
Conclusion: Collectively, our results show that palmitate induces CCL4 expression via activation of the TLR4-MyD88/NF-kB/MAPK/ PI3K signaling cascade. Thus, our findings suggest that the palmitate-induced CCL4 production might be an underlying mechanism of metabolic inflammation.Cell Physiol Biochem 2018;46:953 –964
Source: Cellular Physiology and Biochemistry - April 18, 2018 Category: Cytology Source Type: research

E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage
Conclusion: Here we show, for the first time, the regulation of ELF3 expression by leptin, suggesting that this transcription factor likely mediates the inflammatory responses triggered by leptin in articular chondrocytes.Cell Physiol Biochem 2018;45:2401 –2410
Source: Cellular Physiology and Biochemistry - March 16, 2018 Category: Cytology Source Type: research

Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research

Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy
Conclusion: Endothelial dysfunction in ZDF rats is partially attributable to excessive autophagy. TSG improves endothelial function and exerts hypotensive effectsvia regulation of endothelial autophagy.Cell Physiol Biochem 2017;43:293 –307
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism
Background/Aims: Obese individuals are known to have increased Matrix metalloproteinase (MMP)-9 plasma levels and MMP-9 is reported to play an important role in obesity-associated adipose tissue inflammation. Since in obesity, the levels of circulatory saturated free fatty acid (FFA) palmitate (palimitic acid) are increased and modulate the expression of inflammatory mediators, the role of palmitate in the regulation of MMP-9 remains unclear.Methods:Human monocytic cell line THP-1 and primary monocytes were stimulated with palmitate and TNF- α (positive control). MMP-9 expression was assessed with real time RT-PCR and ELI...
Source: Cellular Physiology and Biochemistry - August 5, 2016 Category: Cytology Source Type: research

CCR4-NOT2 Promotes the Differentiation and Lipogenesis of 3T3-L1 Adipocytes via Upregulation of PPARγ, CEBPα and Inhibition of P-GSK3α/β and β-Catenin
Conclusion: Our findings demonstrate that CNOT2 promotes the differentiation of 3T3-L1 preadipocytes via upregulation of PPAR#x03B3;, and CEBPα and inhibition of GSK3α/β and β-catenin signaling as a potent molecular target for obesity.Cell Physiol Biochem 2015;37:1881-1889
Source: Cellular Physiology and Biochemistry - November 17, 2015 Category: Cytology Source Type: research