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Inhibited Corneal Neovascularization in Rabbits following Corneal Alkali Burn by Double-Target Interference for VEGF and HIF-1 α.
This study aims to investigate the synergistic effects of VEGF and HIF-1α gene silencing on alkali burn-induced CNV in rabbits. The models of rabbits in corneal alkali burn were established. SiRNA recombinant adenovirus was used to explore the synergistic effects of VEGF and HIF-1α gene silencing on alkali burn-induced CNV. CNV area and ultrastructure of cornea were observed. The expression of VEGF and HIF-1α was detected. CNV was observed in rabbits following alkali burn. In addition, overexpressed VEGF and HIF-1α was also observed in rabbits following alkali burn. Then, silencing HIF-1α or silencing VEGF decreased a...
Source: Bioscience Reports - October 24, 2018 Category: Biomedical Science Authors: Fu YC, Xin ZM Tags: Biosci Rep Source Type: research

Nitric oxide promotes epidermal stem cell proliferation via FOXG1-c-Myc signalling
Conclusion This study showed that the biphasic effect of NO on ESC proliferation as well as NO induced ESC proliferation were regulated by the cGMP/FOXG1/c-Myc signalling pathway, suggesting that NO may serve as a new disparate target for wound healing.
Source: Nitric Oxide - December 14, 2017 Category: Chemistry Source Type: research

Dexamethasone downregulates caveolin-1 causing muscle atrophy via inhibited insulin signaling
In this study, we report a new pathway in which glucocorticoids reduce the levels of upstream insulin signaling components by downregulating the transcription of the gene encoding caveolin-1 (CAV1), a scaffolding protein present in the caveolar membrane. Treatment with the glucocorticoid dexamethasone (DEX) decreased CAV1 protein and Cav1 mRNA expression, with a concomitant reduction in insulin receptor alpha (IRα) and IR substrate 1 (IRS1) levels in C2C12 myotubes. On the basis of the results of promoter analysis using deletion mutants and site-directed mutagenesis a negative glucocorticoid-response element in the r...
Source: Journal of Endocrinology - March 19, 2015 Category: Endocrinology Authors: Son, Y. H., Lee, S.-J., Lee, K.-B., Lee, J.-H., Jeong, E. M., Chung, S. G., Park, S.-C., Kim, I.-G. Tags: Research Source Type: research

Adeno-associated virus type 8 vector-mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model.
CONCLUSIONS: These results suggest that siRNA-VEGF can be expressed across the retina and that long-term suppression of CNV is possible through the use of stable AAV2/8-mediated siRNA-VEGF expression. In vivo gene therapy may thus be a feasible approach to the clinical management of CNV in conditions such as age-related macular degeneration. PMID: 24744609 [PubMed - indexed for MEDLINE]
Source: Molecular Vision - November 16, 2014 Category: Molecular Biology Tags: Mol Vis Source Type: research