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Using computational methods to design patient-specific electrospun cardiac patches for pediatric heart failure
Biomaterials. 2022 Feb 18;283:121421. doi: 10.1016/j.biomaterials.2022.121421. Online ahead of print.ABSTRACTAutologous cardiac cell therapy is a promising treatment for combating the right ventricular heart failure (RVHF) that can occur in patients with congenital heart disease (CHD). However, autologous cell therapies suffer from low cell retention following injection and patient-to-patient variability in cell quality. Here, we demonstrate how computational methods can be used to identify mechanisms of cardiac-derived c-Kit+ cell (CPC) reparative capacity and how biomaterials can be designed to improve cardiac patch perf...
Source: Biomaterials - February 26, 2022 Category: Materials Science Authors: Benjamin W Streeter Milton E Brown Preety Shakya Hyun-Ji Park Jichuan Qiu Younan Xia Michael E Davis Source Type: research

Delivery of Nox2-NADPH oxidase siRNA with polyketal nanoparticles for improving cardiac function following myocardial infarction.
This study highlights the potential of polyketals as siRNA delivery vehicles to the MI heart and represents a viable therapeutic approach for targeting oxidative stress. PMID: 23856052 [PubMed - as supplied by publisher]
Source: Biomaterials - July 12, 2013 Category: Materials Science Authors: Somasuntharam I, Boopathy AV, Khan RS, Martinez MD, Brown ME, Murthy N, Davis ME Tags: Biomaterials Source Type: research