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Radiation-induced lipoprotein-associated phospholipase A2 increases lysophosphatidylcholine and induces endothelial cell damage
In this study, radiation-induced LPC accumulation in human aortic endothelial cells (HAECs) increased reactive oxygen species (ROS) production and senescence-associated-beta-galactosidase staining, in addition to decreasing their tube-forming ability. Knockdown of lipoprotein-associated phospholipase A2 (Lp-PLA2) with small interfering RNA (siRNA) inhibited the increased LPC production induced by radiation, and reduced the radiation-induced cell damage produced by ROS and oxidized low-density lipoprotein (LDL). Lp-PLA2 depletion abolished the induction of proinflammatory factors, such as interleukin 1β, tumor necrosis fac...
Source: Toxicology - July 3, 2021 Category: Toxicology Authors: So-Ra Kim Jong-Ik Heo Jeong-Woo Park Chang-Mo Kang Kwang Seok Kim Source Type: research

PTEN mediates serum deprivation-induced cytotoxicity in H9c2 cells via the PI3K/AKT signaling pathway
In conclusion, our study indicated the role of the PTEN/PI3K/AKT pathway in serum deprivation-induced cytotoxicity in H9c2 cells.PMID:33652126 | DOI:10.1016/j.tiv.2021.105131
Source: Toxicology in Vitro - March 2, 2021 Category: Toxicology Authors: Mengmeng Gong Zhiqiang Li Xingxu Zhang Baoxin Liu Jiachen Luo Xiaoming Qin Yidong Wei Source Type: research

FOXO1 silence aggravates oxidative stress-promoted apoptosis in cardiomyocytes by reducing autophagy.
Authors: Ning Y, Li Z, Qiu Z Abstract Mechanisms underlining oxidative stress-induced injury to cardiomyocytes during myocardial infarction (MI) or acute ischemia/reperfusion (I/R) are not well recognized. Forkhead box O (FOXO) transcription factors have been defined as critical mediators of oxidative stress resistance in multiple cell types, but their cardioprotective functions have not been reported previously. In the present study, we investigated the promotion to FOXO1 by the treatment with hydrogen peroxide (H2O2) during the H2O2-induced apoptosis in cardiomyocyte H9c2 cells. We then silenced FOXO1 with FOXO1-...
Source: Journal of Toxicological Sciences - September 13, 2015 Category: Toxicology Tags: J Toxicol Sci Source Type: research