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Activation of Autophagic Flux Blunts Cardiac Ischemia/Reperfusion Injury
Conclusions: Induction of autophagy at the time of reperfusion is sufficient to mitigate myocardial reperfusion injury by reducing ROS and cell death. Maintenance of appropriate autophagic flux may emerge as a viable clinical therapy to reduce reperfusion injury in acute myocardial infarction.PMID:34111934 | DOI:10.1161/CIRCRESAHA.120.318601
Source: Circulation Research - June 11, 2021 Category: Cardiology Authors: Min Xie Geoffrey W Cho Yongli Kong Dan L Li Francisco Altamirano Xiang Luo Cyndi R Morales Nan Jiang Gabriele G Schiattarella Herman I May Jessica Medina John M Shelton Anwarul Ferdous Thomas G Gillette Joseph A Hill Source Type: research

Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-fibrotic Protein Synthesis During Cardiac Fibrosis.
Conclusions: Our results indicate that EPRS preferentially controls translational activation of proline codon rich pro-fibrotic genes in cardiac fibroblasts and augments pathological cardiac remodeling. PMID: 32611237 [PubMed - as supplied by publisher]
Source: Circulation Research - June 30, 2020 Category: Cardiology Authors: Wu J, Subbaiah KCV, Xie LH, Jiang F, Khor ES, Mickelsen DM, Myers JR, Tang WW, Yao P Tags: Circ Res Source Type: research

S1P-S1PR2 Axis Mediates Homing of Muse Cells into Damaged Heart for Long Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction.
Conclusions: Muse cells may provide reparative effects and robust functional recovery, and may thus provide a novel strategy for the treatment of AMI. PMID: 29475983 [PubMed - as supplied by publisher]
Source: Circulation Research - February 23, 2018 Category: Cardiology Authors: Yamada Y, Wakao S, Kushida Y, Minatoguchi S, Mikami A, Higashi K, Baba S, Shigemoto T, Kuroda Y, Kanamori H, Amin M, Kawasaki M, Nishigaki K, Taoka M, Isobe T, Muramatsu C, Dezawa M, Minatoguchi S Tags: Circ Res Source Type: research