Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-fibrotic Protein Synthesis During Cardiac Fibrosis.

Conclusions: Our results indicate that EPRS preferentially controls translational activation of proline codon rich pro-fibrotic genes in cardiac fibroblasts and augments pathological cardiac remodeling. PMID: 32611237 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32611237?dopt=Abstract

Source: Circulation Research - June 30, 2020 Category: Cardiology Authors: Wu J, Subbaiah KCV, Xie LH, Jiang F, Khor ES, Mickelsen DM, Myers JR, Tang WW, Yao P Tags: Circ Res Source Type: research