• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Chaperone Mediated Autophagy Protects Cardiomyocytes Against Hypoxic-Cell Death
This study for the first time establishes a protective role for CMA (via Lamp2a overexpression) against hypoxia-induced cardiomyocyte loss and reveals the intriguing possibility that CMA activation may offer a cardioprotective treatment for ischemic heart disease.PMID:35584327 | DOI:10.1152/ajpcell.00369.2021
Source: Am J Physiol Cell Ph... - May 18, 2022 Category: Cytology Authors: Rajeshwary Ghosh Jennifer Jason Gillaspie Kenneth S Campbell J David Symons Sihem Boudina James Scott Pattison Source Type: research

Specific Inhibition of HDAC4 in Cardiac Progenitor Cells Enhances Myocardial Repairs.
Abstract We have recently shown that in vivo inhibition of histone deacetylase (HDAC) stimulates endogenous myocardial regeneration in infarcted hearts. Furthermore, our observation demonstrates that HDAC inhibition promotes cardiogenesis, which is associated with HDAC4 reduction. However, it remains unknown as to whether specific inhibition of HDAC4 modulates cardiac stem cells (CSCs) to facilitate myocardial repair and to preserve cardiac performance. c-kit(+)CSCs were isolated from adult mouse hearts and were transfected with HDAC4siRNA to knockdown HDAC4 of c-kit(+)CSCs. The transfection of HDAC4siRNA caused a...
Source: Am J Physiol Cell Ph... - June 18, 2014 Category: Cytology Authors: Zhang LX, DeNicola M, Qin X, Du J, Ma J, Zhao TY, Zhuang S, Liu PY, Wei L, Qin G, Tang Y, Zhao TC Tags: Am J Physiol Cell Physiol Source Type: research