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COX-2 Signaling and Cancer: New Players in Old Arena.
Abstract Cancer is a leading cause of death worldwide. The expression of COX-2 and prostaglandins has not only been associated with various types of cancer but is also directly proportional to their aggressiveness including metastasis. Thus, inhibition of COX-2 activity has been one of the preferred targets for cancer reduction. Broad spectrum inhibition of all forms of COX (using NSAIDs) is associated with various side effects ranging from gastric ulceration to renal problems. Even specific COX-2 inhibitors (COXIBS) are associated with side effects like myocardial infarction. Alternative strategies including siRN...
Source: Current Drug Targets - January 26, 2014 Category: Drugs & Pharmacology Authors: Misra S, Sharma K Tags: Curr Drug Targets Source Type: research