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Upregulation of fibroblast growth factor 2 contributes to endometriosis through SPRYs/DUSP6/ERK signaling pathway
Acta Histochem. 2021 Jul 3;123(5):151749. doi: 10.1016/j.acthis.2021.151749. Online ahead of print.ABSTRACTPrevious studies report that fibroblast growth factor 2 (FGF2) modulates Sproutys (SPRYs)/dual specificity phosphatase 6 (DUSP6)/extracellular signal-regulated kinase (ERK) signaling pathway in endometrial glandular epithelial cells. However, its role in endometriosis remains unclear. The expression patterns and localization of related proteins in endometrium patients' samples were determined using quantitative reverse transcription PCR, Western blotting, and immunohistochemistry, respectively. Human endometrial strom...
Source: Acta Histochemica - July 5, 2021 Category: Biochemistry Authors: Xiaoyan Yu Yuping Wang Xiaowei Tan Mingjiang Li Source Type: research

Cai's Neiyi Prescription promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10
AbstractTo observe the effect of Cai's Neiyi Prescription (CNYP) on the apoptosis and inflammation in endometrial stromal cells with endometriosis (EM) bothin vivo andin vitro, EM model rats and endometrial stromal cells were treated with CNYP and the level of USP10, p ‐ERK1/2, ERK1/2, and apoptosis‐related protein as well as the levels of proinflammatory factors were measured by Western blotting and ELISA, respectively. Rats with surgically induced EM showed increased USP10 expression and ERK/2 activation. Intragastric administration of CNYP granule significa ntly inhibited EM‐induced ERK1/2 activation and expressio...
Source: Biotechnology and Applied Biochemistry - December 4, 2018 Category: Biochemistry Authors: Shuangdi Li, Yaping Zhu, Tingting Zhang, Yuanyuan Hang, Qiong Chen, Yuli Jin Tags: Original Article Source Type: research

Cai's Neiyi Prescription  promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10
This article is protected by copyright. All rights reserved
Source: Biotechnology and Applied Biochemistry - November 23, 2018 Category: Biochemistry Authors: Shuangdi Li, Yaping Zhu, Tingting Zhang, Yuanyuan Hang, Qiong Chen, Yuli Jin Tags: Original Article Source Type: research

Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research