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Hyperglycemia Suppresses Calcium Phosphate-Induced Aneurysm Formation Through Inhibition of Macrophage Activation Vascular Medicine
Conclusions Our results show that hyperglycemia suppresses macrophage activation and aneurysmal degeneration through the activation of Nr1h2. Although further validation of the underlying pathway is necessary, targeting Nr1h2 is a potential therapeutic approach to treating aneurysm.
Source: JAHA:Journal of the American Heart Association - March 27, 2016 Category: Cardiology Authors: Tanaka, T., Takei, Y., Yamanouchi, D. Tags: Aneurysm Vascular Medicine Source Type: research

High glucose-induced hyperosmolarity contributes to COX-2 expression and angiogenesis: implications for diabetic retinopathy
Conclusions: Glucose-related hyperosmolarity seems to be able to promote angiogenesis and retinopathy through activation of TonEBP and possibly increasing expression of AQP1 and COX-2. Osmolarity signaling may be a target for therapy.
Source: Cardiovascular Diabetology - January 29, 2016 Category: Cardiology Authors: Rosalinda MadonnaGaia GiovannelliPamela ConfaloneFrancesca RennaYong-Jian GengRaffaele De Caterina Source Type: research