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Irisin attenuates ethanol-induced behavioral deficits in mice through activation of Nrf2 and inhibition of NF- κB pathways
This study aims to investigate the effect of irisin on ethanol-induced behavioral deficits and explore the underlying mechanisms. A mouse model of ethanol addiction/withdrawal was constructed through chronic ethanol administration. Depressive-like behaviors were evaluated by the tail suspension test and forced swimming test, and anxiety-like behaviors were evaluated by the marble-burying test and elevated plus maze test. The expression of Nrf2 was measured by western blotting. Levels of inflammatory mediators (NF- κB, TNF-α, IL-1β and IL-6) and oxidative stress factors (ROS, MDA, GSH and SOD) were detected by ELISA. The...
Source: Metabolic Brain Disease - March 22, 2023 Category: Neurology Source Type: research

Predisposition of Neonatal Maternal Separation to Visceral Hypersensitivity via Downregulation of Small-Conductance Calcium-Activated Potassium Channel Subtype 2 (SK2) in Mice.
Conclusions: ELS-induced visceral pain and visceral hypersensitivity are associated with the underfunction of SK2 channels in the spinal DH. PMID: 33029124 [PubMed - in process]
Source: Neural Plasticity - October 10, 2020 Category: Neurology Authors: Wu K, Gao JH, Hua R, Peng XH, Wang H, Zhang YM Tags: Neural Plast Source Type: research