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Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway
Publication date: Available online 24 November 2018Source: Life SciencesAuthor(s): Runxiao Lv, Lili Du, Lixin Zhang, Zhiqiang ZhangAbstractAimsSpinal cord injury (SCI) is one of the most devastating central lesions, resulting in serious locomotor deficit. Polydatin is a glucoside of resveratrol with proven anti-cardiovascular, anti-inflammatory and anti-oxidative properties. The main purpose of this study was to investigate whether polydatin could alleviate SCI in rats and explore the underlying mechanisms.Materials and methodsSCI rats induced by a weight-drop device were treated with intraperitoneal injection of 20 or 40â...
Source: Life Sciences - November 24, 2018 Category: Biology Source Type: research

Silencing of PHLPP1 promotes neuronal apoptosis and inhibits functional recovery after spinal cord injury in mice
In this study, we investigated the effects of the progression of SCI and potential regulation of apoptosis after the Pleckstrin homology (PH) domain and leucine rich repeat protein phosphatase 1 (PHLPP1) gene was silenced.Main methodsSpinal cord injection, and neuronal transfection with a recombinant adenovirus vector encoding small interfering RNA (siRNA) against PHLPP1 (AdsiPHLPP1) successfully silenced PHLPP1. These created in vivo and in vitro PHLPP1-silenced models, respectively, resulting in stable expression of the transgene in neurons.Key findingsThe results showed that silencing of PHLPP1 evidently reduced levels ...
Source: Life Sciences - August 13, 2018 Category: Biology Source Type: research

Neuroprotective effect of allicin in a rat model of acute spinal cord injury
This study aims to investigate the effect of allicin on motor functions and histopathologic changes after spinal cord injury and the mechanism underlying its neuroprotective effects. Main methods The motor function of rats was evaluated with the Basso, Beattie, and Bresna test. Histopathologic changes were evaluated by hematoxylin and eosin and Nissl staining. Spinal cord oxidative stress markers were determined by measuring glutathione and malondialdehyde content and superoxide dismutase activity using commercial kits. Inflammatory factors were determined by measuring tumor necrosis factor-α, interleukin-1β and interle...
Source: Life Sciences - November 4, 2015 Category: Biology Source Type: research