• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Increased STIM1 expression induced by cigarette smoking extracts regulates the proliferation and production of inflammatory cytokines in human airway smooth muscle cells
This study was supported by NSFC funds NO. 81800015 and 81670038.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Chen, J., Yuan, Z., Zeng, Z., Wang, T., Wen, F. Tags: Airway cell biology and immunopathology Source Type: research

Transient receptor potential canonical 1 channel mediates the mechanical stress ‑induced epithelial‑mesenchymal transition of human bronchial epithelial (16HBE) cells.
Transient receptor potential canonical 1 channel mediates the mechanical stress‑induced epithelial‑mesenchymal transition of human bronchial epithelial (16HBE) cells. Int J Mol Med. 2020 Apr 07;: Authors: Wang J, He Y, Yang G, Li N, Li M, Zhang M Abstract Airway remodeling is a central event in the pathology of chronic obstructive pulmonary disease (COPD) that leads to airway narrowing and subsequently, to increased mechanical pressure. High mechanical pressure can exacerbate airway remodeling. Thus, a treatment regimen aimed at disrupting this high‑pressure airway remodeling vicious cycle may i...
Source: International Journal of Molecular Medicine - April 6, 2020 Category: Molecular Biology Authors: Wang J, He Y, Yang G, Li N, Li M, Zhang M Tags: Int J Mol Med Source Type: research

TRPC channels mediated calcium entry is required for proliferation of human airway smooth muscle cells induced by nicotine-nAChR.
In conclusion, nicotine-induced HASMC proliferation was mediated by TRPC3-dependent calcium entry via α5-nAchR, which provided a potential target for treatment of COPD. PMID: 30550855 [PubMed - as supplied by publisher]
Source: Biochimie - December 11, 2018 Category: Biochemistry Authors: Jiang Y, Zhou Y, Peng G, Tian H, Pan D, Liu L, Yang X, Li C, Li W, Chen L, Ran P, Dai A Tags: Biochimie Source Type: research