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The AMPK-TSC1/2-mTOR signaling pathway regulates cigarette smoking-induced inflammation and apoptosis in airway epithelial cells
Conclusion: mTOR signaling pathway plays an important role in CS–induced airway inflammation and apoptosis, eventually participating in COPD.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Liu, J., Li, W., Ying, S., Shen, H., Chen, Z. Tags: 6.3 Tobacco, Smoking Control and Health Education Source Type: research

Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium
Conclusions These results suggest that CS induces functional CX3CL1 expression in arterial endothelium and leukocytes from patients with COPD show increased CX3CL1-dependent adhesiveness. Therefore, targeting the CX3CL1/CX3CR1 axis might prevent COPD-associated cardiovascular disorders.
Source: Thorax - January 15, 2013 Category: Respiratory Medicine Authors: Rius, C., Company, C., Piqueras, L., Cerda-Nicolas, J. M., Gonzalez, C., Servera, E., Ludwig, A., Morcillo, E. J., Sanz, M.-J. Tags: Health education, Smoking, Health effects of tobacco use, Tobacco use Source Type: research