Critical role of fractalkine (CX3CL1) in cigarette smoke-induced mononuclear cell adhesion to the arterial endothelium

Conclusions
These results suggest that CS induces functional CX3CL1 expression in arterial endothelium and leukocytes from patients with COPD show increased CX3CL1-dependent adhesiveness. Therefore, targeting the CX3CL1/CX3CR1 axis might prevent COPD-associated cardiovascular disorders.

Source: Thorax - January 15, 2013 Category: Respiratory Medicine Authors: Rius, C., Company, C., Piqueras, L., Cerda-Nicolas, J. M., Gonzalez, C., Servera, E., Ludwig, A., Morcillo, E. J., Sanz, M.-J. Tags: Health education, Smoking, Health effects of tobacco use, Tobacco use Source Type: research