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Total 48 results found since Jan 2013.

Supermolecular nanovehicles co-delivering TLR7/8-agonist and anti-CD47 siRNA for enhanced tumor immunotherapy
Int J Biol Macromol. 2023 Aug 25:126539. doi: 10.1016/j.ijbiomac.2023.126539. Online ahead of print.ABSTRACTCancer immunotherapy is the most promising method for tumor therapy in recent years, among which the macrophages play a critical role in the antitumor immune response. However, tumor-associated macrophages (TAMs) usually display the tumor-promoting M2 phenotype rather than the tumor-killing M1 phenotype. Moreover, the over-expressed CD47 on tumor cells severely hinders the function of macrophages by blocking the CD47/SIRPα pathway. Herein, a nano-assembly system of CHTR/siRNA was constructed through the host-guest i...
Source: International Journal of Biological Macromolecules - August 27, 2023 Category: Biochemistry Authors: Tongyi Shang Xinying Yu Yuan Gu Rong Du Yanjun Cai Yuwei Li Guodong Zheng Chaoqun Wang Jian Zhang Jifang Liu Shisong Han Bin Yang Source Type: research

Implementing an Innovative Lipid Management Technique Using siRNA LDL-C Lowering Therapy: Lessons Learned in an NHS Primary Care Practice With Worked Case Examples
CONCLUSIONS: Enhanced lipid management as a secondary prevention measure is achievable in line with national guidance and objectives. The methodology and education/training processes used in combination with reconstructing the management process can help practice staff realize the program benefits, which in turn can lead to a shift in behavior where all staff embed manual case-finding of high-risk patients into everyday consultations and reviews; enabling rapid identification of eligible patients. Taking a multi-disciplinary, holistic approach to new initiatives reduces service burden, particularly for GPs. Leveraging reso...
Source: Primary Care - May 16, 2023 Category: Primary Care Authors: Carl Deaney Meredith Donaldson Agne Meskauskiene Source Type: research

ITGA5 inhibition in pancreatic stellate cells re-educates the in vitro tumor-stromal crosstalk
In this study, ITGA5 in PSCs was inhibited using its specific inhibi tor AV3 peptide or siRNA knockdown technique. Pancreatic cancer SW1990 cells conditioned medium (SW1990-CM) and an indirect co-culture system were used to mimic the environment of the in vitro tumor-stromal crosstalk. Our results showed that ITGA5 inhibition impaired the proliferation and migration of PSCs, but enhanced autophagy. After co-culture with PSCs, SW1990 cells gained some cancer stem cells (CSCs)-like characteristics, such as increased drug resistance, migration and invasion ability, but PSCs with ITGA5 knockdown were incapable of producing the...
Source: Medical Oncology - December 5, 2022 Category: Cancer & Oncology Source Type: research

Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy
An active targeting nanomedicine based on metal-organic frameworks is synthesized through coordination between tannic acid and Fe3+, loaded with anti-TNF- α siRNA and then modified with bovine serum albumin. The nanosystem can selectively accumulate in inflamed joints, be selectively delivered into M1 macrophages, and exert anti-RA efficacy through the synergistic effects between MOF vector and anti-TNF-α siRNA. AbstractMacrophages play essential roles in the progression of rheumatoid arthritis (RA), which are polarized into the pro-inflammatory M1 phenotype with significant oxidative stress and cytokines excretion. Here...
Source: Small - June 3, 2022 Category: Nanotechnology Authors: Lina Guo, Shenghui Zhong, Peng Liu, Man Guo, Jinsong Ding, Wenhu Zhou Tags: Research Article Source Type: research

siRNA as a potential therapy for COVID-19
Curr Drug Deliv. 2021 Aug 5. doi: 10.2174/1567201818666210805145320. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious virus causing COVID-19 disease that severely impacted the world health, education, and economy systems in 2020. The numbers of infection cases and reported deaths are still increasing with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments are under preclinical and clinical investigations now, alongside the race to vaccinate to as much individuals as possible. The genome of SARS-CoV2 share similar...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Ahmad Aljaberi Eman M Migdadi Khalid M Abu Khadra Mahmoud Abu Samak Iman A Basheti Nizar Al-Zoubi Source Type: research

Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer.
Abstract Extracellular vesicles (EVs) are key players of intercellular communication in the physiological and pathological setting. In cancer, EVs mediate complex signaling mechanisms between cancer cells and the tumor microenvironment (TME), and can influence tumor progression and the response to existing therapies. Importantly, EVs can be loaded with therapeutic agents and modified to display tumor-targeting molecules. In the field of nanomedicine, EVs have been engineered to serve as therapeutic delivery vehicles for several anticancer agents, including antibodies, chemotherapy, compounds, CRISPR/Cas9 (clustere...
Source: Endocrinology - February 12, 2021 Category: Endocrinology Authors: Kugeratski FG, McAndrews KM, Kalluri R Tags: Endocrinology Source Type: research