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Knockdown of ALK7 inhibits high glucose-induced oxidative stress and apoptosis in retinal pigment epithelial cells.
Abstract Diabetic retinopathy (DR) is one of the diabetic complications associated with hyperglycemia-mediated oxidative stress. Activin receptor-like kinase 7 (ALK7) has been proven to be a potential therapeutic approach for diabetic cardiomyopathy, which is another diabetic complication. However, the role of ALK7 in DR remains unclear. In the current study, ALK7 was found to be up-regulated in clinical samples from DR patients and high glucose (HG)-induced human retinal pigment epithelial cells (ARPE-19). In vitro studies demonstrated that knockdown of ALK7 in ARPE-19 cells through transfection with siRNA-ALK7 (...
Source: Clinical and Experimental Pharmacology and Physiology - October 13, 2019 Category: Drugs & Pharmacology Authors: Shi Q, Dong X, Zhang M, Cheng Y, Pei C Tags: Clin Exp Pharmacol Physiol Source Type: research