• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Complex roads from genotype to phenotype in dilated cardiomyopathy: scientific update from the Working Group of Myocardial Function of the European Society of Cardiology
This article is part of the Mini Review Series from the Varenna 2017 meeting of the Working Group of Myocardial Function of the European Society of Cardiology.
Source: Cardiovascular Research - May 23, 2018 Category: Cardiology Source Type: research

High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature
Conclusion Our results highlight EC-to-cardiomyocyte transfer of heparanase to modulate the cardiomyocyte cell death signature. This mechanism was observed in the acutely diabetic heart, and its interruption following chronic diabetes may contribute towards the development of diabetic cardiomyopathy.
Source: Cardiovascular Research - December 14, 2016 Category: Cardiology Authors: Wang, F., Jia, J., Lal, N., Zhang, D., Chiu, A. P.-L., Wan, A., Vlodavsky, I., Hussein, B., Rodrigues, B. Tags: Cardiac biology and remodelling Source Type: research

Expression of fibulin-6 in failing hearts and its role for cardiac fibroblast migration
Conclusion Fibulin-6, a fibroblast-released ECM protein, may play an important role during MR by imparting an effect on CF migration in close and complementary interplay with TGF-β1 signalling.
Source: Cardiovascular Research - August 26, 2014 Category: Cardiology Authors: Chowdhury, A., Herzog, C., Hasselbach, L., Khouzani, H. L., Zhang, J., Hammerschmidt, M., Rudat, C., Kispert, A., Gaestel, M., Menon, M. B., Tudorache, I., Hilfiker-Kleiner, D., Muhlfeld, C., Schmitto, J. D., Muller, M., Theilmeier, G. Tags: Cardiac biology and remodelling Source Type: research

Super-resolution fluorescence microscopy of the cardiac connexome reveals plakophilin-2 inside the connexin43 plaque
Conclusions (i) Super-resolution fluorescence microscopy, complemented with Monte–Carlo simulations and PLAs, allows the study of the nanoscale organization of an interactome in cardiomyocytes. (ii) PKP2 and Cx43 share a common hub that permits direct physical interaction. Its relevance to excitability, electrical coupling, and arrhythmogenic right ventricular cardiomyopathy, is discussed.
Source: Cardiovascular Research - October 16, 2013 Category: Cardiology Authors: Agullo-Pascual, E., Reid, D. A., Keegan, S., Sidhu, M., Fenyo, D., Rothenberg, E., Delmar, M. Tags: Cardiac biology and remodelling Source Type: research

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy
Conclusion These findings are consistent with a model in which oxidative damage of the RyR2 targets it for turnover by presenilins and CMA, which could lead to removal of damaged or leaky RyR2 channels.
Source: Cardiovascular Research - April 23, 2013 Category: Cardiology Authors: Pedrozo, Z., Torrealba, N., Fernandez, C., Gatica, D., Toro, B., Quiroga, C., Rodriguez, A. E., Sanchez, G., Gillette, T. G., Hill, J. A., Donoso, P., Lavandero, S. Tags: ORIGINAL ARTICLES: SPOTLIGHT ON T-TUBULES AND RYANODINE RECEPTOR MICRODOMAIN SIGNALLING IN CARDIAC HYPERTROPHY AND FAILURE Source Type: research