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Regulation of NcRNA-protein binding in diabetic foot
In this study, we explored the mechanism and new progress of ncRNA-protein binding in DF, which can provide help and guidance for the application of ncRNA in the early diagnosis and potential targeted intervention of DFU.PMID:36753956 | DOI:10.1016/j.biopha.2023.114361
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 8, 2023 Category: Drugs & Pharmacology Authors: Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu Source Type: research

Irisin attenuates sepsis-induced cardiac dysfunction by attenuating inflammation-induced pyroptosis through a mitochondrial ubiquitin ligase-dependent mechanism
Biomed Pharmacother. 2022 May 30;152:113199. doi: 10.1016/j.biopha.2022.113199. Online ahead of print.ABSTRACTSepsis-induced cardiac dysfunction is a leading cause of mortality in intensive care units. However, the molecular mechanisms underlying septic cardiomyopathy remain elusive. Irisin is a cleaved product of fibronectin type III domain-containing protein 5 (FNDC5) that protects the heart from ischemia/reperfusion injury through upregulation of mitochondrial ubiquitin ligase (MITOL). Gasdermin D (GSDMD)-dependent pyroptosis plays a pivotal role in septic cardiomyopathy by regulating mitochondrial homeostasis. However,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 2, 2022 Category: Drugs & Pharmacology Authors: Xiang Xiong Linhe Lu Zhenyi Wang Jipeng Ma Yalan Shao Yang Liu Mengen Zhai Ping Jin Jian Yang Qijun Zheng Jincheng Liu Lifang Yang Source Type: research