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Combination of Quercetin or/and siRNA-loaded DDAB-mPEG-PCL hybrid nanoparticles reverse resistance to Regorafenib in colon cancer cells
Colorectal cancer (CRC) is the second leading cause of cancer death. Although Regorafenib showed survival benefits in patients with CRC, reports imply the recurrence of malignant phenotype resulting from chemo...
Source: BMC Complementary and Alternative Medicine - December 27, 2022 Category: Complementary Medicine Authors: Shabnam Shahidi, Kobra Rostamizadeh, Mojtaba Fathi, Keivan Nedaei and Ali Ramazani Tags: Research Source Type: research

PARP14 regulates EP4 receptor expression in human colon cancer HCA-7  cells
Biochem Biophys Res Commun. 2022 Jul 19;623:133-139. doi: 10.1016/j.bbrc.2022.07.055. Online ahead of print.ABSTRACTE type prostanoid 4 (EP4) receptors and their signaling pathways have been implicated in the development and malignant transformation of colorectal cancer. We herein demonstrated that the mono(ADP-ribosyl)ation of histone deacetylase (HDAC)1 and HDAC2 by poly(ADP-ribose) polymerase 14 (PARP14) may be required to induce the expression of EP4 receptors. The suppression of PARP14 activity by siRNA and/or its inhibitors reduced the mRNA expression of EP4 receptors. Thus, the expression of their proteins to approx...
Source: Biochemical and Biophysical Research communications - August 1, 2022 Category: Biochemistry Authors: Masato Mashimo Asuka Shimizu Aimi Mori Ayaka Hamaguchi Keijo Fukushima Naofumi Seira Takeshi Fujii Hiromichi Fujino Source Type: research

Ethanol Extract of Lycopus lucidus Turcz. ex Benth Inhibits Metastasis by Downregulation of Runx-2 in Mouse Colon Cancer Cells.
This study aims to elucidate the effects of ethanol extracts of LT (ELT) relative to the role of Runt-related transcription factor- (Runx-) 2 in the invasive and metastatic potentials of mouse colon cancer to determine the underlying mechanisms involved. ELT was evaluated for the antimetastasis activity using CT-26 colon cancer using wound healing, transwell matrigel, and western blot analysis. We used Runx-2-specific siRNA to further determine the relationship between Runx-2 and matrix metalloprotease- (MMP-) 9 in the migration and invasion of CT-26 cells. Runx-2 was first demonstrated to be a transcription factor that pl...
Source: Evidence-based Complementary and Alternative Medicine - August 16, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research