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Source: Cell Research
Cancer: Skin Cancer
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Total 22 results found since Jan 2013.
Downregulated BIRC5 inhibits proliferation and metastasis of melanoma through the β-catenin/HIF-1α/VEGF/MMPs pathway
CONCLUSION: Our findings revealed that ZWZ-3 could downregulate BIRC5 and inhibit melanoma proliferation and metastasis through the β-catenin/HIF-1α/VEGF/MMPs pathway. Therefore, BIRC5 represents a promising therapeutic target for the treatment of melanoma.PMID:37728702 | DOI:10.1007/s00432-023-05425-3
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Qingqing He Yijing He Changqiang Li Jianv Wang Tong Xia Xia Xiong Jixiang Xu Li Liu Source Type: research
3-deazaneplanocin A, a histone methyltransferase inhibitor, improved the chemoresistance induced under hypoxia in melanoma cells
In conclusion, a histone methyltransferase EZH2 inhibitor, DZNep was capable of tackling acquired chemoresistance via the suppression of histone methylation induced under hypoxic tumor microenvironment.PMID:37542772 | DOI:10.1016/j.bbrc.2023.08.003
Source: Cell Research - August 5, 2023 Category: Cytology Authors: Mika Hosokawa Sekai Tetsumoto Mirano Yasui Yusuke Kono Ken-Ichi Ogawara Source Type: research
TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
CONCLUSIONS: Our results reveal the antioxidant and cisplatin resistance-regulating roles of the TNFAIP2/KEAP1/NRF2/JNK axis in HNSCC, suggesting that TNFAIP2 might be a potential target in improving the cisplatin treatment effect, particularly for patients with cisplatin resistance.PMID:37525222 | PMC:PMC10391982 | DOI:10.1186/s13046-023-02775-1
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Teng Xu Yuemei Yang Zhihong Chen Jinsong Wang Xiaolei Wang Yang Zheng Chao Wang Yachen Wang Zaiou Zhu Xu Ding Junbo Zhou Gang Li Hongchuang Zhang Wei Zhang Yunong Wu Xiaomeng Song Source Type: research
LAMC2 regulates proliferation, migration, and invasion mediated by the Pl3K/AKT/mTOR pathway in oral
CONCLUSIONS: LAMC2 interacts with autophagy to regulate OSCC metastasis, invasion, and proliferation via the PI3K/AKT/mTOR pathway. LAMC2 down-regulation can synergistically modulate autophagy to inhibit OSCC migration, invasion, and proliferation.PMID:37415741 | PMC:PMC10319602 | DOI:10.32604/or.2023.029064
Source: Cell Research - July 7, 2023 Category: Cytology Authors: Fayu Shan Lanlan Liang Chong Feng Hongbao Xu Zirou Wang Weili Liu Lingling Pu Zhaoli Chen Gang Chen Xinxing Wang Source Type: research
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
CONCLUSIONS: Our study identifies important gene regulatory functions for YAP/TAZ-TEAD-TP63 in the early stages of lung cancer development, which notably includes immune-suppressive roles, and suggest that an assessment of the activity of this transcriptional complex may offer a means to identify immune evasive bronchial PMLs and serve as a potential therapeutic target.PMID:37150829 | DOI:10.1186/s13046-023-02674-5
Source: Cell Research - May 7, 2023 Category: Cytology Authors: Boting Ning Andrew M Tilston-Lunel Justice Simonetti Julia Hicks-Berthet Adeline Matschulat Roxana Pfefferkorn Avrum Spira Matthew Edwards Sarah Mazzilli Marc E Lenburg Jennifer E Beane Xaralabos Varelas Source Type: research
MYC induces immunotherapy and interferon- γ resistance through downregulation of JAK2
Cancer Immunol Res. 2023 Apr 19:CIR-22-0184. doi: 10.1158/2326-6066.CIR-22-0184. Online ahead of print.ABSTRACTImmunotherapy has revolutionized the treatment of advanced melanoma. Because the pathways mediating resistance to immunotherapy are largely unknown, we conducted transcriptome profiling of pre-immunotherapy tumor biopsies from melanoma patients that received PD-1 blockade or adoptive cell therapy with tumor-infiltrating lymphocytes. We identified two melanoma-intrinsic, mutually exclusive gene programs, which were controlled by interferon-γ (IFNγ) and MYC, and the association with immunotherapy outcome. MYC-over...
Source: Cell Research - April 19, 2023 Category: Cytology Authors: Ettai Markovits Ortal Harush Erez N Baruch Eldad D Shulman Assaf Debby Orit Itzhaki Liat Anafi Artem Danilevsky Noam Shomron Guy Ben-Betzalel Nethanel Asher Ronnie Shapira-Frommer Jacob Schachter Iris Barshack Tamar Geiger Ran Elkon Michal J Besser Gal Ma Source Type: research
SOX10 Inhibits T Cell Recognition by Inducing Expression of the Immune Checkpoint Molecule PD-L1 in A375 Melanoma Cells
CONCLUSION: SOX10 has a role in the intrinsic immune suppressive mechanisms of melanoma through expression of PD-L1.PMID:36974807 | DOI:10.21873/anticanres.16296
Source: Cell Research - March 28, 2023 Category: Cytology Authors: Kenta Sasaki Yoshihiko Hirohashi Kenji Murata Tomoyuki Minowa Munehide Nakatsugawa Aiko Murai Yuka Mizue Terufumi Kubo Takayuki Kanaseki Tomohide Tsukahara Sadahiro Iwabuchi Shinichi Hashimoto Hisashi Uhara Akemi Ishida-Yamamoto Toshihiko Torigoe Source Type: research
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
CONCLUSIONS: This research indicated that targeting LCN2 could be a promising strategy for the treatment of OSCC.PMID:36899380 | DOI:10.1186/s13046-023-02618-z
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Zixian Huang Xi Rui Chen Yi Yongju Chen Rui Chen Yancan Liang Yan Wang Weicheng Yao Xiaoding Xu Zhiquan Huang Source Type: research
Oncogenic < em > BRAF < /em > < sup > V600E < /sup > induces microglial proliferation through extracellular signal-regulated kinase and neuronal death through c-Jun N-terminal kinase
Neural Regen Res. 2023 Jul;18(7):1613-1622. doi: 10.4103/1673-5374.361516.ABSTRACTActivating V600E in v-Raf murine sarcoma viral oncogene homolog B (BRAF) is a common driver mutation in cancers of multiple tissue origins, including melanoma and glioma. BRAFV600E has also been implicated in neurodegeneration. The present study aims to characterize BRAFV600E during cell death and proliferation of three major cell types of the central nervous system: neurons, astrocytes, and microglia. Multiple primary cultures (primary cortical mixed culture) and cell lines of glial cells (BV2) and neurons (SH-SY5Y) were employed. BRAFV600E ...
Source: Cell Research - December 26, 2022 Category: Cytology Authors: Qing Ye Pranay Srivastava Nasser Al-Kuwari Xiqun Chen Source Type: research
A novel molecular mechanism of vascular fibrosis in Takayasu arteritis: macrophage-derived GPNMB promoting adventitial fibroblast extracellular matrix production in the aorta
This study provides evidence that targeting GPNMB is a potential therapeutic strategy for treating vascular fibrosis in TAK.PMID:36566014 | DOI:10.1016/j.trsl.2022.12.004
Source: Cell Research - December 24, 2022 Category: Cytology Authors: Xiaojuan Dai Ying Sun Lingying Ma Jun Hou Li Wang Yu Gong Xiaoning Sun Sifan Wu Jinghua Wang Zongfei Ji Huiyong Chen Lili Ma Lindi Jiang Xiufang Kong Source Type: research
Silencing of SiX-4 enhances the chemosensitivity of melanoma cells to Cisplatin
In this study, we investigated whether silencing of SIX4 in a melanoma cell line (A375 cells) in combination with Cisplatin can affect the apoptosis and suppression of cell cycle progression, migration of the melanoma cells. MTT test and colony formation assay was applied to determine the IC50 of Cisplatin and the combined effect of SIX4 siRNA and Cisplatin on the viability and clonogenesis of the A-375 cells. qRT-PCR was performed to determine the c-myc, BCL-2, BAX, MMP-9, CXCR4, and Rock genes expression. Furthermore, flow cytometry was applied to evaluate apoptosis, autophagy, and the cell cycle status in different grou...
Source: Cell Research - November 12, 2022 Category: Cytology Authors: Aysan Fallah Vazirabad Saeed Noorolyai Elham Baghbani Soltanali Mahboob Felor Zargari Shima Rahmani Amin Sorkhabi Nooshin Montazami Pouriya Sameti Behzad Baradaran Source Type: research
EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression
This study establishes loss of dependency on EPAC-mTORC1 signaling as hallmark of primary melanoma evolution and targeting this escape mechanism is a promising strategy for metastatic melanoma.PMID:35834616 | DOI:10.1158/1541-7786.MCR-22-0026
Source: Cell Research - July 14, 2022 Category: Cytology Authors: Aishwarya Krishnan Aishwarya I Bhasker Mithalesh K Singh Carlos I Rodriguez Edgardo Castro-Perez Sarah Altameemi Marcos Lares Hamidullah Khan Mary Ndiaye Nihal Ahmad Stefan M Schieke Vijayasaradhi Setaluri Source Type: research
The Potential Key Role of the NRF2/NQO1 Pathway in the Health Effects of Arsenic Pollution on SCC
In this study, we found that arsenite can promote the transformation of immortalized human keratinocyte cells (HaCaT) from the G0/G1 phase to S phase and demonstrated malignant phenotypes. This phenomenon is accompanied by obviously elevated levels of NRF2, NQO1, Cyclin E, and Cyclin-dependent kinase 2 (CDK2). Silencing the NRF2 expression with small interfering RNA (siRNA) in arsenite-transformed (T-HaCaT) cells was shown to reverse the malignant phenotype. Furthermore, the siRNA silencing of NQO1 significantly decreased the levels of the cyclin E-CDK2 complex, inhibiting the G0/G1 to S phase cell cycle progression and tr...
Source: Cell Research - July 9, 2022 Category: Cytology Authors: Qianlei Yang Rui Yan Yuemei Mo Haixuan Xia Hanyi Deng Xiaojuan Wang Chunchun Li Koichi Kato Hengdong Zhang Tingxu Jin Jie Zhang Yan An Source Type: research
Dual inhibition of autophagy and PI3K/mTOR pathway as a potential therapeutic strategy against laryngeal squamous cell carcinoma
CONCLUSIONS: NVP-BEZ235 exerted potent antitumor effects on LSCC, especially when combined with the autophagy inhibitor both in vitro and vivo, providing convincing experimental data for new molecular targeted therapy for LSCC.PMID:35706786 | PMC:PMC9189222 | DOI:10.21037/tcr-21-2325
Source: Cell Research - June 16, 2022 Category: Cytology Authors: Hui-Ying Huang Ke-Nan Li Hui-Ching Lau Chi-Yao Hsueh Ning Cong Ming Zhang Source Type: research
