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Cancer: Ovarian Cancer
Therapy: Statin Therapy
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Total 2 results found since Jan 2013.
Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library.
This study is the first comprehensive analysis in discovering potential endocrine disrupters which affect the ERRĪ± signaling pathway.
PMID: 29216352 [PubMed - as supplied by publisher]
Source: Endocrinology - December 4, 2017 Category: Endocrinology Authors: Lynch C, Zhao J, Huang R, Kanaya N, Bernal L, Hsieh JH, Auerbach SS, Witt KL, Merrick BA, Chen S, Teng CT, Xia M Tags: Endocrinology Source Type: research
Oxysterols Synergize with Statins by Inhibiting SREBP-2 in Ovarian Cancer Cells.
CONCLUSIONS: We provide evidence of statins' mechanisms of cytotoxicity in different ovarian cancer cells and discovered a new approach to significantly enhance the anti-tumor activity of statins. These observations provide a potential new path to improve statins as a treatment against ovarian cancer with obtainable dosages.
PMID: 25134999 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - August 15, 2014 Category: Cancer & Oncology Authors: Casella C, Miller DH, Lynch K, Brodsky AS Tags: Gynecol Oncol Source Type: research
