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GSE240039 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein ATAC
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of ...
Source: GEO: Gene Expression Omnibus - August 10, 2023 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

GSE236275 Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS family protein
Contributors : Tomoyuki Nanamiya ; Kiyoko Takane ; Kiyoshi Yamaguchi ; Yoichi FurukawaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensNectin-4 or PVRL4 is a promising therapeutic target because its augmented expression has been found in a wide range of human cancers. It is of note that Enfortumab Vedotin, an ADC for PVRL4 is clinically used for the treatment of urothelial bladder cancer. In addition, rMV-SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through an interaction with PVRL4. Although the transcripts of PVRL4 are elev...
Source: GEO: Gene Expression Omnibus - July 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE185932 Gene expression changes associated with reducing Sox2 expression in ovarian cancer cell line PA1 under anchorage independence
The objective of this study is to examine the effect of changing Sox2 expression under the conditions of anchorage independent growth that is known to drive the expression of survival genes. We compared genome wide gene expression profiles of the ovarian tumor cell line PA1 upon transient knockdown of Sox2 expression using siRNA and compared to negative silencer control siRNA cells. Cells grown in biological triplicates were transfected under steady state 2D growth conditions and then transferred to poly-hema coated plates to prevent attachment. After 72 hrs, RNA was collected from siSox2 and sicontrol cells followed by ve...
Source: GEO: Gene Expression Omnibus - July 26, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE142567 RNA sequencing (RNA-SEQ) of FOXM1 knockdown by siRNA in ovarian cancer cells
Conclusions: These data reveal FOXM1 as a driver oncogenic transcription factor that promotes ovarian cancer malignancy which might be a potential drug target in HGSOC.
Source: GEO: Gene Expression Omnibus - December 1, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE181078 RNA sequencing of DDX23 knockdown by siRNA in ovarian cancer cells
In this study, DDX23 was first identified as a key DEAD-box RNA helicase in ovarian cancer, and its overexpressed was associated with poor clinical outcomes. High expression of DDX23 was involved in the malignant proliferation and aggressiveness of ovarian cancer.
Source: GEO: Gene Expression Omnibus - July 31, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE153839 RNA sequencing (RNA-SEQ) of RECQL4 knockdown by siRNA in ovarian cancer cells
Contributors : Li Guo ; Yingwei LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe high frequency of somatic copy number alterations, as opposed to point mutations, is considered a unique feature of high-grade serous ovarian carcinoma (HGSOC). Amplification-dependent overexpression of RECQL4, which participates in DNA replication and repair, mediates the development of various cancers, but its pathobiological and clinical roles are poorly understood. Here, using bioinformatics analysis, RECQL4 amplification was found to occur in 27% of HGSOC samples in the TCGA cohort. RECQL4 was f...
Source: GEO: Gene Expression Omnibus - October 13, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE153440 NanoString gene expression data of OCI-C5x and OCI-P5x
Contributor : Reid ShawSeries Type : Expression profiling by arrayOrganism : Homo sapiensGene expression data of two ovarian carcinoma patient-derived cells was analyzed with respect to high-throughput functional siRNA screens and small-molecule screens.
Source: GEO: Gene Expression Omnibus - June 30, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE119845 Analysis of miRNA profiles in mucinous ovarian cancer cells that silenced PRKRA.
Contributor : Takeshi HisamatsuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWe compared miRNAs expression in mucinous ovarian cancer cell between treated with siPRKRA and contrl siRNA. We hypothesize that PRKRA regulates chemosensitivity in mucinous ovarian cancer. Therefore, we aim to idetify the PRKRA-mediated miRNA which regulate chemosensitivity in mucinous ovarian cancer.
Source: GEO: Gene Expression Omnibus - January 1, 2019 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

GSE66894 Identification of JMJD1A and JMJD2B Target Genes in Hypoxic Ovarian Cancer Cells
Contributors : Lei Qiu ; Adam J KriegSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. Using transcript profiling, we have identified genes that are regulated by JMJD1A and JMJD2B in both normoxic and hypoxic conditions in SKOV3ip.1 ovarian cancer cells.This dataset includes expression data obtained from exposing ovarian cancer cells to hypoxia in combination with siRNA-mediated knockdown of t...
Source: GEO: Gene Expression Omnibus - March 13, 2017 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE78704 BRD4 represses CBX5
Contributors : Marianne Kim ; Christina M AnnunziataSeries Type : Expression profiling by arrayOrganism : Homo sapiensBRD4 is amplified and/or up-regiulated in a subset of ovarian cancer which correlates with a poor survivalsiRNA sensitization screens in the presence of CHK1 inhibitor, LY2606368, identify BRD4 as a therapeutic target in ovarian cancer. BRD4 suppression by either siRNA or using JQ1 increases CBX5 expression
Source: GEO: Gene Expression Omnibus - May 1, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research