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CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77
CONCLUSIONS: Since CC1007 demonstrates remarkable anti-MM effect on MM cells, it may be a promising drug for the treatment of MM.PMID:36283176 | DOI:10.1016/j.bioorg.2022.106217
Source: Bioorganic Chemistry - October 25, 2022 Category: Chemistry Authors: Shicong Zhu Cheng Xing Guangsen Zhang Hongling Peng Zhihua Wang Source Type: research

Autocrine and Paracrine Interactions between Multiple Myeloma Cells and Bone Marrow Stromal Cells by Growth Arrest-specific Gene 6 Cross-talk with Interleukin-6 Signal Transduction
The pathogenesis of multiple myeloma (MM) has not yet been fully elucidated. Our microarray analysis and immunohistochemistry revealed significant up-regulation of growth arrest-specific gene 6 (Gas6), a vitamin K-dependent protein with a structural homology with protein S, in bone marrow (BM) cells of MM patients. ELISA showed that the serum levels of soluble Gas6 were significantly increased in the MM patients when compared with healthy controls. Gas6 was overexpressed in the human CD138-positive MM cell line RPMI-8226. Exogenous Gas6 suppressed apoptosis induced by serum deprivation and enhanced cell proliferation of th...
Source: Journal of Biological Chemistry - March 9, 2017 Category: Chemistry Authors: Miki Furukawa, Hiroshi Ohkawara, Kazuei Ogawa, Kazuhiko Ikeda, Koki Ueda, Akiko Shichishima-Nakamura, Emi Ito, Jun-ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Takayuki Ikezoe, Yasuchika Takeishi Tags: Cell Biology Source Type: research

Molecules, Vol. 22, Pages 276: Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase
Ginkgolic acid C 17:1 (GAC 17:1) extracted from Ginkgo biloba leaves, has been previously reported to exhibit diverse antitumor effect(s) through modulation of several molecular targets in tumor cells, however the detailed mechanism(s) of its actions still remains to be elucidated. Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that regulates various critical functions involved in progression of diverse hematological malignancies, including multiple myeloma, therefore attenuating STAT3 activation may have a potential in cancer therapy. We determined the anti-tumor mechanism ...
Source: Molecules - February 12, 2017 Category: Chemistry Authors: Seung Baek Jong Lee Chulwon Kim Jeong-Hyeon Ko Seung-Hee Ryu Seok-Geun Lee Woong Yang Jae-Young Um Arunachalam Chinnathambi Sulaiman Alharbi Gautam Sethi Kwang Ahn Tags: Article Source Type: research