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Cancer: Myeloma

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Total 122 results found since Jan 2013.

Inhibition of VCP modulates NF- κB signaling pathway to suppress multiple myeloma cell proliferation and osteoclast differentiation
This study aims to identify if VCP is a therapeutic target in MM and confirm the effect of a novel inhibitor of VCP (VCP20) on MM. We found that VCP was elevated in MM patients and correlated with shorter survival in clinical TT2 cohort. Silencing VCP using siRNA resulted in decreased MM cell proliferation via NF-κB signaling pathway. VCP20 evidently inhibited MM cell proliferation and osteoclast differentiation. Moreover, exosomes containing VCP derived from MM cells partially alleviated the inhibitory effect of VCP20 on cell proliferation and osteoclast differentiation. Mechanism study revealed that VCP20 inactivated th...
Source: Aging - August 22, 2023 Category: Biomedical Science Authors: Rongfang Wei Yuhao Cao Hongjie Wu Xin Liu Mingmei Jiang Xian Luo Zhendong Deng Ze Wang Mengying Ke Yongqiang Zhu Siqing Chen Chunyan Gu Ye Yang Source Type: research

FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in multiple myeloma
Leuk Res. 2023 Jun 17;132:107343. doi: 10.1016/j.leukres.2023.107343. Online ahead of print.ABSTRACTForkhead box K2 (FOXK2) is a transcription factor involved in regulating the pathophysiological processes in many types of cancers. Functioning as either an oncogene or tumor suppressor, FOXK2 is involved in cell proliferation, metastasis, DNA damage, metabolism, and autophagy. However, the functions of FOXK2 in multiple myeloma (MM) are still unexplored. Here we show that FOXK2 silencing by small interfering RNA (siRNA) prevented the expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) via dephosphor...
Source: Cell Research - June 25, 2023 Category: Cytology Authors: Xinling Liu Na Tang Yong Liu Jieting Fu Yao Zhao Haihua Wang Haiying Wang Zhenbo Hu Source Type: research

BDNF/TrkB confers bortezomib resistance in multiple myeloma by inducing BRINP3
CONCLUSIONS: BDNF/TrkB enhanced downstream pathway expression of phosphorylation STAT3 and BRINP3 molecules, promoting RPMI 8226/BTZ cell proliferating and survival.GENERAL SIGNIFICANCE: These data place BDNF/TrkB at the top of a pSTAT3-BRINP3 survival pathway and link adaptability to BTZ resistant conditions in MM disease.PMID:36565997 | DOI:10.1016/j.bbagen.2022.130299
Source: Biochimica et Biophysica Acta - December 24, 2022 Category: Biochemistry Authors: Li Bao Yutong Wang Minqiu Lu Lei Shi Bin Chu Shan Gao Source Type: research

Bim downregulation by activation of NF- κB p65, Akt, and ERK1/2 is associated with adriamycin and dexamethasone resistance in multiple myeloma cells
In this study, we examined the MDR mechanism in adriamycin- and dexamethasone-resistant cells. RPMI8226/ADM, ARH-77/ADM, RPMI8226/DEX, and ARH-77/DEX cells exhibited enhanced nuclear factor κB (NF-κB) p65, Akt, and extracellular signal-regulated kinase 1/2 (ERK1/2) activation. Combination treatment with NF-κB p65, phosphoinositide 3-kinase (PI3K), and mitogen-activated protein kinase 1/2 (MEK1/2) inhibitors resensitized to adriamycin and dexamethasone via increased Bim expression. A lthough treatment with MDR1 or Survivin siRNA did not overcome adriamycin and dexamethasone resistance in RPMI8226/ADM and RPMI8226/DEX cel...
Source: Clinical and Experimental Medicine - November 30, 2022 Category: Research Source Type: research

Cancers, Vol. 14, Pages 5621: Guggulsterone Induces Apoptosis in Multiple Myeloma Cells by Targeting High Mobility Group Box 1 via Janus Activated Kinase/Signal Transducer and Activator of Transcription Pathway
. Bhat Shahab Uddin Multiple myeloma (MM) is a hematological disorder characterized by the abnormal expansion of plasma cells in the bone marrow. Despite great advances over the past three decades in discovering the efficacious therapies for MM, the disease remains incurable for most patients owing to emergence of drug-resistant cancerous cells. Guggulsterone (GS), a phytosteroid, extracted from the gum resin of guggul plant, has displayed various anticancer activities in vitro and in vivo; however, the molecular mechanisms of its anticancer activity have not been evaluated in MM cells. Therefore, in this study, we i...
Source: Cancers - November 16, 2022 Category: Cancer & Oncology Authors: Sabah Akhtar Lubna Zarif Shilpa Kuttikrishnan Kirti S. Prabhu Kalyani Patil Sabah Nisar Haissam Abou-Saleh Maysaloun Merhi Said Dermime Ajaz A. Bhat Shahab Uddin Tags: Article Source Type: research

CC1007, a small molecular compound, suppresses multiple myeloma via upregulation of Nur77
CONCLUSIONS: Since CC1007 demonstrates remarkable anti-MM effect on MM cells, it may be a promising drug for the treatment of MM.PMID:36283176 | DOI:10.1016/j.bioorg.2022.106217
Source: Bioorganic Chemistry - October 25, 2022 Category: Chemistry Authors: Shicong Zhu Cheng Xing Guangsen Zhang Hongling Peng Zhihua Wang Source Type: research

DAZAP1 facilitates the alternative splicing of KITLG to promote multiple myeloma cell proliferation via ERK signaling pathway
In conclusion, we establish DAZAP1 as a tumor-promoting gene with therapeutic potential and provide mechanistic insights into targeting DAZAP1 as a new strategy for the diagnosis and treatment of MM.PMID:36242590 | DOI:10.18632/aging.204326
Source: Aging - October 15, 2022 Category: Biomedical Science Authors: Yanyan Zhou Shaohua Huangfu Muxi Li Chao Tang Jinjun Qian Mengjie Guo Zuojian Zhou Ye Yang Chunyan Gu Source Type: research

Gene expression profiling and in vitro functional studies reveal RAD54L as a potential therapeutic target in multiple myeloma
CONCLUSIONS: This study has identified possible molecular targets underlying the pathogenesis of MM. For the first time, we reveal RAD54L as a potential therapeutic target in MM, possibly functioning in the cell cycle and checkpoint control.PMID:35689754 | DOI:10.1007/s13258-022-01272-7
Source: Cancer Control - June 11, 2022 Category: Cancer & Oncology Authors: Ivyna Pau Ni Bong Ching Ching Ng Norodiyah Othman Ezalia Esa Source Type: research