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MT2-MMP is differentially expressed in multiple myeloma cells and mediates their growth and progression
Cell Signal. 2022 Jan 15:110248. doi: 10.1016/j.cellsig.2022.110248. Online ahead of print.ABSTRACTOBJECTIVE: Membrane type-matrix metalloproteinases (MT-MMPs) are known as key regulators of cancer progression/metastasis. However, their roles in the growth and progression of multiple myeloma (MM) have not been yet elucidated.METHODS AND MATERIALS: The expression of 6 MT-MMPs in MM, B cell lines, and normal peripheral blood (PB) cells were measured by RT-PCR, qRT-PCR, flow cytometry, western blotting, and immunocytochemistry. B lymphocytes, CD19-/CD138-, and CD19-/CD138+ cells, known as malignant plasma cells (MPC), were so...
Source: Cellular Signalling - January 18, 2022 Category: Cytology Authors: Shohreh Fakhari Ali Jalili Bahram Nikkhoo Bayazid Ghaderi Mohammad Amin Boshagh Sako Mirzaie Mohammad Moradzad Source Type: research

Importin β1 mediates nuclear factor-κB signal transduction into the nuclei of myeloma cells and affects their proliferation and apoptosis.
In conclusion, our results clearly show that Importin β1 mediates the translocation of NF-κB into the nuclei of myeloma cells, thereby regulating proliferation and blocking apoptosis, which provides new insights for targeted myeloma therapies. PMID: 25643631 [PubMed - as supplied by publisher]
Source: Cellular Signalling - January 30, 2015 Category: Cytology Authors: Yan W, Li R, He J, Du J, Hou J Tags: Cell Signal Source Type: research