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Exosomes Derived from Cancer Associated Fibroblasts Elicit Survival and Drug Resistance of Primary Lymphoma Cells
ConclusionOur results suggest that CAFs and exosomes secreted from them are involved in the survival and drug resistance of patient lymphoma cells and play a pivotal role in the microenvironment of non-Hodgkin lymphoma. Exosomes would be a novel attractive therapeutic target.DisclosuresKiyoi: Sanofi K.K.: Research Funding; Kyowa Hakko Kirin Co., Ltd.: Research Funding; Otsuka Pharmaceutical Co., Ltd.: Research Funding; Nippon Shinyaku Co., Ltd.: Research Funding; Celgene Corporation: Research Funding; Zenyaku Kogyo Co., Ltd.: Research Funding; Eisai Co., Ltd.: Research Funding; FUJIFILM Corporation: Research Funding; Chuga...
Source: Blood - November 21, 2018 Category: Hematology Authors: Kunou, S., Shimada, K., Hikita, T., Aoki, T., Sakamoto, A., Hayakawa, F., Oneyama, C., Kiyoi, H. Tags: 622. Lymphoma Biology-Non-Genetic Studies: Poster III Source Type: research

Upregulation of ADAM12 contributes to accelerated cell proliferation and cell adhesion-mediated drug resistance (CAM-DR) in Non-Hodgkin's Lymphoma.
CONCLUSION AND DISCUSSION: Our data support a role for ADAM12 in NHL cell proliferation, adhesion, and drug resistance, and it may pave the way for a novel therapeutic approach for CAM-DR in NHL. PMID: 28395594 [PubMed - as supplied by publisher]
Source: Hematology - April 12, 2017 Category: Hematology Tags: Hematology Source Type: research