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Polo-like kinase 4 is associated with advanced TNM stages and reduced survival and its inhibition improves chemosensitivity in colorectal cancer
In conclusion, the high expression of tumor PLK4 was associated with advanced TNM stage and shorter OS in patients with CRC. In addition, targeting PLK4 improved chemosensitivity in CRC cells.PMID:35782899 | PMC:PMC9247664 | DOI:10.3892/ol.2022.13389
Source: Oncology Letters - July 5, 2022 Category: Cancer & Oncology Authors: Zhengang Duan Lei Cai Jin Cao Wei Wu Source Type: research

Expression of sphingosine-1-phosphate receptor 2 is correlated with migration and invasion of human colon cancer cells: A preliminary clinical study
Oncol Lett. 2022 Jun 1;24(1):241. doi: 10.3892/ol.2022.13361. eCollection 2022 Jul.ABSTRACTSphingosine-1-phosphate (S1P) is a bioactive phospholipid that serves as a potent mediator of cell proliferation, differentiation and apoptosis by binding to S1P receptors (S1PRs). S1P signalling is involved in the pathogenesis of numerous types of disease, including cancer. To the best of our knowledge, however, little is known about the expression patterns of S1PRs and their role in human colorectal cancer (CRC) cell migration and invasion. The aim of the present study was to investigate the role of S1P signalling in the metastasis...
Source: Oncology Letters - June 20, 2022 Category: Cancer & Oncology Authors: Junjun Yan Yi Chen Qibiao Wu Le Shao Xiqiao Zhou Source Type: research

Regulatory effect between HMGA2 and the Wnt/ β-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma
Oncol Lett. 2021 Dec;22(6):849. doi: 10.3892/ol.2021.13110. Epub 2021 Oct 25.ABSTRACTDue to the high incidence of colorectal cancer worldwide, the underlying molecular mechanisms have been extensively investigated. The Wnt/β-catenin signaling pathway plays a key role in the carcinogenesis of colorectal adenoma. In addition, the high mobility group AT-hook 2 (HMGA2) protein, which is involved in several biological processes, such as proliferation, differentiation, transformation and metastasis, is expressed at significantly high levels in colorectal cancer tissues compared with adjacent normal tissues. Currently, the role ...
Source: Oncology Letters - November 4, 2021 Category: Cancer & Oncology Authors: Dan Li Yanan Cao Juan Wang Haiyan Yang Weina Liu Jinfeng Cui Wenxin Wu Source Type: research

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