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Total 2131 results found since Jan 2013.
siRNA and targeted delivery systems in breast cancer therapy
AbstractRecently, nucleic acid drugs have been considered as promising candidates in treatment of various diseases, especially cancer. Because of developing resistance to conventional chemotherapy, use of genetic tools in cancer therapy appears inevitable. siRNA is a RNAi tool with capacity of suppressing target gene. Owing to overexpression of oncogenic factors in cancer, siRNA can be used for suppressing those pathways. This review emphasizes the function of siRNA in treatment of breast tumor. The anti-apoptotic-related genes including Bcl-2, Bcl-xL and survivin can be down-regulated by siRNA in triggering cell death in ...
Source: Clinical and Translational Oncology - December 23, 2022 Category: Cancer & Oncology Source Type: research
CBL inhibits proliferation and invasion of breast cancer cells by ubiquitylation-mediated degradation of NCK2
CONCLUSION: CBL can inhibit the proliferation, migration and invasion of breast cancer cells through ubiquitination-mediated degradation of NCK2.PMID:36504051 | PMC:PMC9742774 | DOI:10.12122/j.issn.1673-4254.2022.11.02
Source: Journal of Southern Medical University - December 12, 2022 Category: Universities & Medical Training Authors: X Song B Xiao J Lu W Zhang J Li X Zhu Z Sun L Li Source Type: research
