Filtered By:
Source: J Cell Mol Med
Cancer: Hypopharyngeal Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 2 results found since Jan 2013.
Targeting STAT3 prevents bile reflux-induced oncogenic molecular events linked to hypopharyngeal carcinogenesis
J Cell Mol Med. 2021 Dec 1. doi: 10.1111/jcmm.17011. Online ahead of print.ABSTRACTThe signal transducer and activator of transcription 3 (STAT3) oncogene is a transcription factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to acidic bile present aberrant activation of STAT3, possibly contributing to its oncogenic effect. We hypothesized that STAT3 contributes substantially to the bile reflux-induced molecular oncogenic profile, which can be suppressed by STAT3 silencing or pharmacological inhibition. To explore our hypothesis, we targeted the STAT3 pathway, by knocking down STAT3 (STAT...
Source: J Cell Mol Med - December 1, 2021 Category: Molecular Biology Authors: Dimitra P Vageli Panagiotis G Doukas Athanasios Siametis Benjamin L Judson Source Type: research
