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Lentivirus-Mediated Short Hairpin RNA for Follistatin Downregulation Suppresses Tumor Progression in Hypopharyngeal Carcinoma
ConclusionsOur results indicated that the FST gene was associated with HPC progression and may serve as a potential therapeutic target for the treatment of HPC.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - July 21, 2022 Category: Research Source Type: research

Targeting STAT3 prevents bile reflux-induced oncogenic molecular events linked to hypopharyngeal carcinogenesis
J Cell Mol Med. 2021 Dec 1. doi: 10.1111/jcmm.17011. Online ahead of print.ABSTRACTThe signal transducer and activator of transcription 3 (STAT3) oncogene is a transcription factor with a central role in head and neck cancer. Hypopharyngeal cells (HCs) exposed to acidic bile present aberrant activation of STAT3, possibly contributing to its oncogenic effect. We hypothesized that STAT3 contributes substantially to the bile reflux-induced molecular oncogenic profile, which can be suppressed by STAT3 silencing or pharmacological inhibition. To explore our hypothesis, we targeted the STAT3 pathway, by knocking down STAT3 (STAT...
Source: J Cell Mol Med - December 1, 2021 Category: Molecular Biology Authors: Dimitra P Vageli Panagiotis G Doukas Athanasios Siametis Benjamin L Judson Source Type: research

Cancers, Vol. 11, Pages 1848: The Potential Impact of Connexin 43 Expression on Bcl-2 Protein Level and Taxane Sensitivity in Head and Neck Cancers –In Vitro Studies
This study aimed to test the role of Cx43 protein on Bcl-2 expression, tumor progression and response to taxane-based treatment in HNSCC. Human papillomavirus (HPV) negative HNSCC cell lines were tested for paclitaxel sensitivity through measuring apoptosis induction, cell viability and changes in Cx43 and Bcl-2 levels using flow cytometry, cell viability assay, immunocytochemistry and western blot. Inhibition of Cx43 expression using siRNA increased Bcl-2 protein levels in SCC25 (tongue squamous cell carcinoma) cells, while forced Cx43 expression reduced Bcl-2 levels and supported paclitaxel cytotoxicity in FaDu (hypophar...
Source: Cancers - November 21, 2019 Category: Cancer & Oncology Authors: Bianka Gurbi Di ána Brauswetter Attila Varga P ál Gyulavári Kinga P énzes J ózsef Murányi Veronika Z ámbó Ede Birtalan Tibor Kren ács David Laurence Becker Mikl ós Csala Istv án Vályi-Nagy Istv án Peták Korn él Dános Tags: Article Source Type: research

GSE85614 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines Panc-1, FaDu and PC3
Contributors : Naohiko Seki ; Keiichi KoshizukaSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, hypopharyngeal squamous cell carcinoma and prostate cancer) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - August 16, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE82108 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (III)
Contributors : Naohiko Seki ; Yusuke GotoSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (pancreatic cancer, esophageal cancer, tongue squamous cell carcinoma, hypopharyngeal squamous cell carcinoma and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - June 3, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

GSE56243 Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines
Contributor : Naohiko SekiSeries Type : Expression profiling by arrayOrganism : Homo sapiensTo identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines (bladder cancer, prostate cancer, hypopharyngeal cancer and lung squamous cell carcinoma) were subjected to Agilent whole genome microarrays.
Source: GEO: Gene Expression Omnibus - April 13, 2016 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research

Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma.
Authors: Kakuki T, Kurose M, Takano KI, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Takahashi S, Hatakeyama T, Kohno T, Himi T, Kojima T Abstract Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is a tight junction molecule associated with epithelial and endothelial barrier function. Overexpression of JAM-A is also closely associated with invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer. However, little is known about the mechanism in overexpression of JAM-A in head and neck squamous cell carcinoma (HNSCC). In the present study, w...
Source: Oncotarget - April 3, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Cleavage and cell adhesion properties of human epithelial cell adhesion molecule (HEPCAM). Additions and Corrections
VOLUME 290 (2015) PAGES 24574–24591During the generation of CRISPR-Cas9-mediated knock-out clones, the HCT-8 (rectum carcinoma) cell line was substituted for the FaDu (hypopharynx carcinoma) cell line. As a result, all of the data described in Figs. 6 and 7 represent results derived from cells of rectum carcinoma cell line HCT-8 and not FaDu cells. The conclusions drawn from results depicted in Figs. 6 and 7 have not been related to specific carcinoma entities, and the data are further substantiated by the use of siRNA and shRNA in esophageal carcinoma cell line Kyse30. The conclusions of the paper are not affected by this correction.
Source: Journal of Biological Chemistry - January 1, 2016 Category: Chemistry Authors: Tsaktanis, T., Kremling, H., Pavšič, M., von Stackelberg, R., Mack, B., Fukumori, A., Steiner, H., Vielmuth, F., Spindler, V., Huang, Z., Jakubowski, J., Stoecklein, N. H., Luxenburger, E., Lauber, K., Lenarčič, B., Gires, O. Tags: Additions and Corrections Source Type: research