• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells
CONCLUSION: The signaling pathway of ANGPTL4 in CCA progression might be regulated by PRKDC and RPL21. Furthermore, high expression of ANGPTL4-related signaling proteins has potential to be used in clinical prognosis.PMID:35732325 | DOI:10.21873/cgp.20335
Source: Genomics Proteomics ... - June 22, 2022 Category: Genetics & Stem Cells Authors: Tin May Aung Atit Silsirivanit Apinya Jusakul Waraporn Chan-On Tanakorn Proungvitaya Sittiruk Roytrakul Siriporn Proungvitaya Source Type: research

GSE171974 JMJD6 is a possible epigenetic regulator of PD-L1 expression and an independent favorable prognostic factor of intrahepatic cholangiocarcinoma
Contributors : Yukiko Kosai-Fujimoto ; Daisuke Okuzaki ; Takasuke FukuharaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAssociation of Jumonji domain-containing 6 (JMJD6) with outcomes of various cancers has been shown, however the impact on intrahepatic cholangiocarcinoma (ICC) has never been reported yet. The aim of this study is to clarify the role of JMJD6 in the clinical settings and the impact on the outcomes of ICC. The resected liver specimens of 53 patients who underwent surgery for ICC were analyzed for JMJD6 expression by immunohistochemistry staining. The relationship be...
Source: GEO: Gene Expression Omnibus - March 23, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

GSE140498 Hepatocytic c-Jun N-terminal kinases (JNK)-1/2 function determines cell fate during carcinogenesis
Contributors : F J Cubero ; M R Mohamed ; M V Boekschoten ; C TrautweinSeries Type : Expression profiling by arrayOrganism : Mus musculusAberrant biliary hyperproliferation resulting from lack of differentiating signals favoring the maintenance of an immature and proliferative phenotype by biliary epithelial cells are ultimately responsible for ducto/cystogenesis and intrahepatic cholangiocarcinoma (CCA) formation. Mitogen-activated protein kinase (MAPK) signaling is pivotal for CCA-related tumorigenesis. In particular, targeted inhibition of JNK signaling has shown therapeutic potential. However, the cell-type specific ro...
Source: GEO: Gene Expression Omnibus - June 8, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Knockdown of tripartite motif 59 (TRIM59) inhibits proliferation in cholangiocarcinoma via the PI3K/AKT/mTOR signalling pathway.
CONCLUSIONS: Our study revealed that TRIM59 is up-regulated in CCA tissues and cell lines and promoted CCA cell proliferation, possibly by affecting the PI3K/AKT/mTOR signalling pathway. PMID: 30822475 [PubMed - as supplied by publisher]
Source: Gene - February 25, 2019 Category: Genetics & Stem Cells Authors: Shen H, Zhang J, Zhang Y, Feng Q, Wang H, Li G, Jiang W, Li X Tags: Gene Source Type: research

Modulation of Notch signaling as a therapeutic approach for liver cancer.
Abstract Notch signaling is an evolutionarily conserved pathway crucial for the development and homeostasis of many organs including liver. Aberrant Notch signaling has been mechanistically linked to cancer development including liver cancer. The two principal types of liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (IHCC). HCCs comprise over 80% of all liver cancers and are the 6th most common malignancy worldwide. Hepatocellular carcinoma is also a cancer with an extremely poor prognosis, being the 3rd commonest cause of cancer-related mortality. Accumulating evidence indicate...
Source: Current Gene Therapy - December 23, 2014 Category: Genetics & Stem Cells Authors: Wu G, Wilson G, George J, Qiao L Tags: Curr Gene Ther Source Type: research