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Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression
ConclusionOur results suggest that MDR1 is an attractive therapeutic target for chemoresistant OS. Tumor-specific virotherapy is thus a promising strategy for reversing chemoresistance in OS patients via suppression of MDR1 expression.
Source: Cancer Chemotherapy and Pharmacology - June 10, 2021 Category: Cancer & Oncology Source Type: research

Silencing of VEGF inhibits human osteosarcoma angiogenesis and promotes cell apoptosis via VEGF/PI3K/AKT signaling pathway.
CONCLUSION: Our data demonstrated that VEGF silencing could suppress cells proliferation, promote cells apoptosis and reduce osteosarcoma angiogenesis through inactivation of VEGF/PI3K/AKT signaling pathway. PMID: 27158386 [PubMed]
Source: American Journal of Translational Research - May 10, 2016 Category: Research Tags: Am J Transl Res Source Type: research

CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice
Conclusions Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain. Inhibition of spinal CRTC1 expression reduced bone cancer pain. Interruption to the positive feedback circuit between CREB/CRTC1 and its targets may contribute to the analgesic effects. These findings may provide further insight into the mechanisms and treatment of bone cancer pain.
Source: Molecular Pain - April 7, 2016 Category: Molecular Biology Authors: Liang, Y., Liu, Y., Hou, B., Zhang, W., Liu, M., Sun, Y.-E., Ma, Z., Gu, X. Tags: Research Article Source Type: research

Positive feedback regulation between microRNA‐132 and CREB in spinal cord contributes to bone cancer pain in mice
ConclusionsThese findings suggest that activation of spinal CREB/CRTC1 signalling may play an important role in bone cancer pain. Interruption to the positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 can effectively relieved the bone cancer‐induced mechanical allodynia and spontaneous pain. What does this study add?The positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 in spinal cord plays an important role in bone cancer pain.
Source: European Journal of Pain - February 26, 2016 Category: Anesthesiology Authors: B. Hou, X. Cui, Y. Liu, W. Zhang, M. Liu, Y.E. Sun, Z. Ma, X. Gu Tags: Original Article Source Type: research

Positive feedback regulation between microRNA ‐132 and CREB in spinal cord contributes to bone cancer pain in mice
ConclusionsThese findings suggest that activation of spinal CREB/CRTC1 signalling may play an important role in bone cancer pain. Interruption to the positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 can effectively relieved the bone cancer‐induced mechanical allodynia and spontaneous pain. What does this study add?The positive feedback regulation between CREB/CRTC1 and its target gene miR‐132 in spinal cord plays an important role in bone cancer pain.
Source: European Journal of Pain - February 25, 2016 Category: Anesthesiology Authors: B. Hou, X. Cui, Y. Liu, W. Zhang, M. Liu, Y.E. Sun, Z. Ma, X. Gu Tags: Original Article Source Type: research

Abstract 342: Telomerase-dependent oncolytic adenovirus sensitizes human osteosarcoma cells to chemotherapy through Mcl-1 downregulation
In this study, we investigated the chemosensitizing effect of OBP-301 in human osteosarcoma cells and the molecular mechanism in the OBP-301-mediated enhancement of cell death. We used four human osteosarcoma cell lines, HOS, MNNG/HOS, 143B and SaOS-2. OBP-301 is an attenuated adenovirus, in which the hTERT promoter drives the expression of E1 gene, and causes tumor-selective lysis in a variety of human malignant tumor cells with telomerase activity. OBP-301 infection enhanced the cytotoxic effect of chemotherapeutic agents, cisplatin and doxorubicin, that are commonly used for the treatment of osteosarcomas. The calculati...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Osaki, S., Omori, T., Tazawa, H., Hasei, J., Yamakawa, Y., Sasaki, T., Kunisada, T., Urata, Y., Ozaki, T., Fujiwara, T. Tags: Molecular and Cellular Biology Source Type: research