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Specialty: Gastroenterology
Cancer: Carcinoma
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Total 175 results found since Jan 2013.
Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts anti-tumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis
RNA N6-Methyladenosine (m6A) reader protein YTHDF1 has been implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in nonalcoholic steatohepatitis-associated HCC (NASH-HCC), remains unknown. Here, we investigated the functional role and molecular mechanism of YTHDF1 on NASH-HCC and its interplay with tumor immune microenvironment.
Source: Journal of Hepatology - July 15, 2023 Category: Gastroenterology Authors: Lina Wang, Lefan Zhu, Cong Liang, Xiang Huang, Ziqin Liu, Jihui Huo, Ying Zhang, Yifan Zhang, Lili Chen, Hongzhi Xu, Xiaoxing Li, Lixia Xu, Ming Kuang, Chi Chun Wong, Jun Yu Source Type: research
Targeting N6-methyladenosine reader YTHDF1 with siRNA boosts antitumor immunity in NASH-HCC by inhibiting EZH2-IL-6 axis
RNA N6-methyladenosine (m6A) reader protein YTHDF1 has been implicated in cancer; however, its role in hepatocellular carcinoma (HCC), especially in non-alcoholic steatohepatitis-associated HCC (NASH-HCC), remains unknown. Here, we investigated the functional role of YTHDF1 in NASH-HCC and its interplay with the tumor immune microenvironment.
Source: Journal of Hepatology - July 15, 2023 Category: Gastroenterology Authors: Lina Wang, Lefan Zhu, Cong Liang, Xiang Huang, Ziqin Liu, Jihui Huo, Ying Zhang, Yifan Zhang, Lili Chen, Hongzhi Xu, Xiaoxing Li, Lixia Xu, Ming Kuang, Chi Chun Wong, Jun Yu Tags: Research Article Source Type: research
Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma < em > via < /em > the PI3K/AKT pathway
CONCLUSION: Our study suggests for the first time that DDX51 promotes cancer cell proliferation by regulating the PI3K/AKT pathway; thus, DDX51 might be a therapeutic target for ESCC.PMID:35125830 | PMC:PMC8790558 | DOI:10.3748/wjg.v28.i4.464
Source: World Journal of Gastroenterology - February 7, 2022 Category: Gastroenterology Authors: Dong-Xin Hu Qi-Feng Sun Lin Xu Hong-Da Lu Fan Zhang Zhen-Miao Li Ming-Yan Zhang Source Type: research
