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Inhibiting the glycerophosphodiesterase EDI3 in ER-HER2+ breast cancer cells resistant to HER2-targeted therapy reduces viability and tumour growth
CONCLUSIONS: Our results indicate that EDI3 may be a potential novel therapeutic target in patients with HER2-targeted therapy-resistant ER-HER2 + breast cancer that should be further explored.PMID:36670508 | DOI:10.1186/s13046-022-02578-w
Source: Cell Research - January 20, 2023 Category: Cytology Authors: Magdalena Keller Katharina Rohlf Annika Glotzbach Gregor Leonhardt Simon L üke Katharina Derksen Özlem Demirci Defne G öçener Mohammad AlWahsh J örg Lambert Cecilia Lindskog Marcus Schmidt Walburgis Brenner Matthias Baumann Eldar Zent Mia-Lisa Zischi Source Type: research

PI3K inhibitors in trastuzumab-resistant HER2-positive breast cancer cells with PI3K pathway alterations
We examined three HER2-positive, ER-negative breast cancer cell lines to determine the efficacy of a novel alpha isoform-specific PI3K inhibitor in combination with trastuzumab. The results indicated that this combination was effective in PIK3CA-mutant or PTEN-deficient breast cancer cells by inducing apoptosis and inhibiting the expression of downstream proteins. PTEN loss by siRNA modulation in parental HER2-positive cancer cells with PI3K signaling pathway alterations could not confer resistance to alpelisib or GDC-0077 plus trastuzumab. We selected the CK-MB-1 cell line without alterations in the PI3K pathway to demons...
Source: Cell Research - August 15, 2022 Category: Cytology Authors: Wei-Pang Chung Wei-Lun Huang Chun-Hui Lee Hui-Ping Hsu Wan-Ling Huang You-Yu Liu Wu-Chou Su Source Type: research

Efp promotes growth of triple-negative breast cancer cells
Biochem Biophys Res Commun. 2022 Jul 30;624:81-88. doi: 10.1016/j.bbrc.2022.07.071. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is characterized by its high ability of invasiveness and metastasis, namely lacking expression of estrogen receptor (ER), progesterone receptor, and HER2. We previously demonstrated that estrogen responsive finger protein (Efp) plays a tumor-promotive role in ER-positive breast cancer, yet it remains to be addressed whether Efp contributes to TNBC pathophysiology. We here found that Efp mRNA and protein were abundantly expressed in TNBC patient-derived cells and MDA-MB-231 c...
Source: Cell Research - August 8, 2022 Category: Cytology Authors: Wataru Sato Kazuhiro Ikeda Noriko Gotoh Satoshi Inoue Kuniko Horie Source Type: research

Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer
CONCLUSIONS: Our study shows that CRC resistance to EGFR inhibitors results primarily from the inability of the inhibitors to downregulate their target and that a PEPDG278D-based combination treatment overcomes the resistance.PMID:35650607 | DOI:10.1186/s13046-022-02389-z
Source: Cell Research - June 1, 2022 Category: Cytology Authors: Lu Yang Arup Bhattacharya Yun Li Sandra Sexton Xiang Ling Fengzhi Li Yuesheng Zhang Source Type: research

HER2 promotes epithelial-mesenchymal transition through regulating osteopontin in gastric cancer
CONCLUSIONS: These findings indicate that HER2 may promote EMT via the regulation of OPN in GCs.PMID:34634565 | DOI:10.1016/j.prp.2021.153643
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Yalan Liu Lingli Chen Dongxian Jiang Lijuan Luan Jie Huang Yingyong Hou Chen Xu Source Type: research

ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells.
Abstract While androgen deprivation therapy (ADT) reduces tumor burden, autocrine growth factor loops such as human epidermal growth factor receptor 2 (HER2/ErbB-2/neu) have been proposed to contribute to prostate cancer (PCa) survival and relapse. However, the role of ErbB-2 in regulating androgen-sensitive (AS) and castration-resistant (CR) cell proliferation remains unclear. Here, we determined the role of ErbB-2 in PCa progression and survival under steroid-reduced conditions using two independent PCa cell progression models. In AR-positive androgen-independent (AI) PCa cells that exhibit the CR phenotype, Erb...
Source: Cellular Signalling - August 6, 2015 Category: Cytology Authors: Muniyan S, Chen SJ, Lin FF, Wang Z, Mehta PP, Batra SK, Lin MF Tags: Cell Signal Source Type: research