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Cancer: HER2
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Total 260 results found since Jan 2013.
Efp promotes growth of triple-negative breast cancer cells
Biochem Biophys Res Commun. 2022 Jul 30;624:81-88. doi: 10.1016/j.bbrc.2022.07.071. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is characterized by its high ability of invasiveness and metastasis, namely lacking expression of estrogen receptor (ER), progesterone receptor, and HER2. We previously demonstrated that estrogen responsive finger protein (Efp) plays a tumor-promotive role in ER-positive breast cancer, yet it remains to be addressed whether Efp contributes to TNBC pathophysiology. We here found that Efp mRNA and protein were abundantly expressed in TNBC patient-derived cells and MDA-MB-231 c...
Source: Cell Research - August 8, 2022 Category: Cytology Authors: Wataru Sato Kazuhiro Ikeda Noriko Gotoh Satoshi Inoue Kuniko Horie Source Type: research
PI3K inhibitors in trastuzumab-resistant HER2-positive breast cancer cells with PI3K pathway alterations
We examined three HER2-positive, ER-negative breast cancer cell lines to determine the efficacy of a novel alpha isoform-specific PI3K inhibitor in combination with trastuzumab. The results indicated that this combination was effective in PIK3CA-mutant or PTEN-deficient breast cancer cells by inducing apoptosis and inhibiting the expression of downstream proteins. PTEN loss by siRNA modulation in parental HER2-positive cancer cells with PI3K signaling pathway alterations could not confer resistance to alpelisib or GDC-0077 plus trastuzumab. We selected the CK-MB-1 cell line without alterations in the PI3K pathway to demons...
Source: Cell Research - August 15, 2022 Category: Cytology Authors: Wei-Pang Chung Wei-Lun Huang Chun-Hui Lee Hui-Ping Hsu Wan-Ling Huang You-Yu Liu Wu-Chou Su Source Type: research
S100A9 promotes glycolytic activity in HER2-positive breast cancer to induce immunosuppression in the tumour microenvironment
CONCLUSIONS: S100A9 overexpression upregulated the glycolysis activity of tumour cells through the c-Myc-related pathway, suppressing lymphocyte infiltration in the tumour stroma, affecting the efficacy of immune regulation and long-term survival of patients.PMID:36755606 | PMC:PMC9900376 | DOI:10.1016/j.heliyon.2023.e13294
Source: Cancer Control - February 9, 2023 Category: Cancer & Oncology Authors: Jia-Qi Yuan Shou-Man Wang Lei Guo Source Type: research
