SiRNA/rss/search.php?qu=siRNA/rss/search.php?qu=siRNA/rss/search.php?qu=siRNA RSS Page 11

Filtered By:
Specialty: Biology

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 85360 results found since Jan 2013.

Necrotizing pneumonia due to Aspergillus and Salmonella after immune checkpoint inhibitor treatment: An unusual case and review of the literature
CONCLUSIONS: Awareness of unusual pathogens in the etiology of pneumonia after ICI treatment may help to avoid underdiagnosis.PMID:37714729 | DOI:10.1016/j.riam.2023.05.001
Source: Revista Iberoamericana de Micologia - September 15, 2023 Category: Biology Authors: Muhammed Cihan I şık O ğuz Karcıoğlu G ülşen Hazırolan Dolunay G ülmez Mehmet Ruhi Onur Mehmet Mahir Kunt Sevtap Arikan-Akdagli G ökhan Metan Source Type: research

Reactive Oxygen Species-Mediated Mitophagy and Cell Apoptosis are Involved in the Toxicity of Aluminum Chloride Exposure in GC-2spd
This study aimed to examine the impact of AlCl3 exposure on mitophagy and mitochondrial apoptosis in testicular tissue and mouse spermatocytes. Reactive oxygen species (ROS) and ATP levels were measured in GC-2spd after AlCl3 exposure using a multifunctional enzyme labeler. The changes in mitochondrial membrane potential (MMP) and TUNEL were observed through confocal laser microscopy, and the expression of proteins associated with mitophagy and apoptosis was analyzed using Western blot. Our results demonstrated that AlCl3 exposure disrupted mitophagy and increased apoptosis-related protein expression in testicular tissues....
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Hui- Xin Peng Fu Chai Ke-Heng Chen Yan-Xin Huang Guang-Ji Wei Huixiong Yuan Yan-Fang Pang Shi-Hua Luo Chun-Fang Wang Wen-Cheng Chen Source Type: research

Lead, Cadmium, and Arsenic in Raw Milk Produced in the Vicinity of a Mini Mineral Concentrator in the Central Andes and Health Risk
This study evaluated the potential risk to human health from lead (Pb), cadmium (Cd), and arsenic (As) from the consumption of milk produced in an area of the Central Andes valley near a mini mineral concentrator by estimating the weekly intake (WI), dietary risk quotient (DRC), hazard quotient (THQ), and hazard index (HI) for the Peruvian population aged 2 to 85 years, in three scenarios of milk consumption by age (minimum, average, and maximum). Toxic element quantification was performed by flame atomic absorption spectrometry following standardized procedures. The mean amount ± standard deviation of Pb, Cd, and As in s...
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Doris Chirinos-Peinado Jorge Castro-Bedri ñana Elva R íos-Ríos Gianfranco Castro-Chirinos Yubaly Quispe-Poma Source Type: research

Size, Surface Properties, and Ion Release of Zinc Oxide Nanoparticles: Effects on Cytotoxicity, Dopaminergic Gene Expression, and Acetylcholinesterase Inhibition in Neuronal PC-12 Cells
Biol Trace Elem Res. 2023 Sep 15. doi: 10.1007/s12011-023-03832-8. Online ahead of print.ABSTRACTThe extensive applications of zinc oxide nanoparticles (ZnO NPs) have resulted in a substantial risk of human exposure. However, the knowledge of the toxicity of these NPs in the nervous system is still limited. A comparative analysis of ZnO NPs of various sizes and NPs of the same size, with and without surface coating, and the potential role of released zinc ions is yet to be thoroughly explored. As a result, we have studied the cellular toxicity of two different-sized ZnO NPs, ZnO-22 (22 nm) and ZnO-43 (43 nm), and NPs with ...
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Jitendra Kumar Suthar Anuradha Vaidya Selvan Ravindran Source Type: research

Evaluation of the Therapeutic Effect of Curcumin-Conjugated Zinc Oxide Nanoparticles on Reserpine-Induced Depression in Wistar Rats
In conclusion, curcumin-conjugated zinc oxide nanoparticles demonstrate potent antidepressant effects, alleviating depressive-like behavior in rats. These findings support Zn(cur)O NPs as a promising therapeutic strategy for depression management, warranting further investigation and clinical validation.PMID:37713054 | DOI:10.1007/s12011-023-03849-z
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Heba M Fahmy Fatmaalzahraa A Aboalasaad Ayman S Mohamed Fathi A Elhusseiny Yasser A Khadrawy Ahmed Elmekawy Source Type: research

Reference Intervals of Serum Iodine Concentration in Chinese Pregnant Women
Biol Trace Elem Res. 2023 Sep 15. doi: 10.1007/s12011-023-03859-x. Online ahead of print.ABSTRACTThe study aims to establish trimester-specific reference ranges for serum iodine (SI) in Chinese pregnant women and explore its associations with maternal and infantile thyroid function. Apparently healthy pregnant women were enrolled during their first antenatal visit. Fasting venous and spot urine samples were collected for determining serum and urinary iodine (UI) levels by a validated inductively coupled plasma mass spectrometry. Serum free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSH), and neonatal TSH le...
Source: Biological Trace Element Research - September 15, 2023 Category: Biology Authors: Yi Wu Huan-Huan Long Su-Juan Zhang Min-Min Li Chao-Gang Chen Cheng Wang Zheng-Yu Sheng Yan-Bin Ye Shu-Yu Zuo Wen-Jing Pan Zhao-Min Liu Source Type: research

Regulation of PIN polarity in response to abiotic stress
Curr Opin Plant Biol. 2023 Sep 14:102445. doi: 10.1016/j.pbi.2023.102445. Online ahead of print.ABSTRACTPlants have evolved robust adaptive mechanisms to withstand the ever-changing environment. Tightly regulated distribution of the hormone auxin throughout the plant body controls an impressive variety of developmental processes that tailor plant growth and morphology to environmental conditions. The proper flow and directionality of auxin between cells is mainly governed by asymmetrically localized efflux carriers - PINs - ensuring proper coordination of developmental processes in plants. Discerning the molecular players ...
Source: Current Opinion in Plant Biology - September 15, 2023 Category: Biology Authors: Manvi Sharma Petra Marhava Source Type: research

Nrf2 depletion in the context of loss-of-function Keap1 leads to mitolysosome accumulation
Free Radic Biol Med. 2023 Sep 13:S0891-5849(23)00627-5. doi: 10.1016/j.freeradbiomed.2023.09.009. Online ahead of print.ABSTRACTTranscription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the principal determinant of the cellular redox homeostasis, contributing to mitochondrial function, integrity and bioenergetics. The main negative regulator of Nrf2 is Kelch-like ECH associated protein 1 (Keap1), a substrate adaptor for Cul3/Rbx1 ubiquitin ligase, which continuously targets Nrf2 for ubiquitination and proteasomal degradation. Loss-of-function mutations in Keap1 occur frequently in lung cancer, leading ...
Source: Free Radical Biology and Medicine - September 15, 2023 Category: Biology Authors: Sharadha Dayalan Naidu Plamena R Angelova Elena V Knatko Chiara Leonardi Miroslav Novak Laureano de la Vega Ian G Ganley Andrey Y Abramov Albena T Dinkova-Kostova Source Type: research

cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis
This study mainly explores the role and mechanism of STING in hypoxia-related renal fibrosis. To address this issue, we stimulated human proximal tubular epithelial (HK-2) cells with hypoxia for 48 h to construct cell models. Meanwhile, C57BL/6J male mice were used to establish a renal fibrosis model induced by renal ischemia-reperfusion injury (IRI). In our present study, we found that the GMP-AMP synthase (cGAS)-STING signaling pathway can promote the progression of renal fibrosis after hypoxic exposure, and this effect is closely related to 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 (PFKFB3)-mediated glycol...
Source: Free Radical Biology and Medicine - September 15, 2023 Category: Biology Authors: Anni Jiang Jing Liu Yumei Wang Chun Zhang Source Type: research

Direct recruitment of Mis18 to interphase spindle pole bodies promotes CENP-A chromatin assembly
Curr Biol. 2023 Sep 8:S0960-9822(23)01143-0. doi: 10.1016/j.cub.2023.08.063. Online ahead of print.ABSTRACTCENP-A chromatin specifies mammalian centromere identity, and its chaperone HJURP replenishes CENP-A when recruited by the Mis18 complex (Mis18C) via M18BP1/KNL2 to CENP-C at kinetochores during interphase. However, the Mis18C recruitment mechanism remains unresolved in species lacking M18BP1, such as fission yeast. Fission yeast centromeres cluster at G2 spindle pole bodies (SPBs) when CENP-ACnp1 is replenished and where Mis18C also localizes. We show that SPBs play an unexpected role in concentrating Mis18C near cen...
Source: Current Biology - September 15, 2023 Category: Biology Authors: Nitobe London Bethan Medina-Pritchard Christos Spanos Juri Rappsilber A Arockia Jeyaprakash Robin C Allshire Source Type: research

Origins of slow growth on the crocodilian stem lineage
We present new osteohistological data from a broad sample of early crocodylomorphs, evaluated in a phylogenetic context alongside other pseudosuchians. We find that the transition to slow-growing bone types during mid-late ontogeny occurred around the origin of Crocodylomorpha during the Late Triassic. Earlier-diverging pseudosuchians had high maximum growth rates, as indicated by the presence of woven bone during middle and (sometimes) late ontogeny.6,7,8,9 Large-bodied pseudosuchians in particular exhibit some of the fastest-growing bone types, giving evidence for prolonged, rapid growth. By contrast, early-branching cro...
Source: Current Biology - September 15, 2023 Category: Biology Authors: Jennifer Botha Bailey M Weiss Kathleen Dollman Paul M Barrett Roger B J Benson Jonah N Choiniere Source Type: research

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20