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Specialty: Virology
Vaccination: Influenza Vaccine
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Total 178 results found since Jan 2013.
Identification of γ-Fagarine as a novel antiviral agent against respiratory virus (hMPV) infection
In this study, we aim to investigate the effect of γ-Fagarine on hMPV infection and explore its underlying molecular mechanisms. Vero-E6 and 16HBE cells were used as cell models. Virus replication and microcosm character were explored in Vero-E6 cells. Then, the antiviral activities were investigated by quantitative real-time PCR (RT-qPCR), western blotting (WB), and indirect immunofluorescence assays (IFAs) in Vero-E6 and 16HBE. Potential mechanisms of γ-Fagarine related to HSPG and lysosome pH were assessed in 16HBE cells. Lastly, a virus-infected mouse model was established and antiviral assay in vivo was conducted. Î...
Source: Virus Research - September 21, 2023 Category: Virology Authors: Jinhua Li Yao Zhao Ying Dai Junning Zhao Source Type: research
TWiV 1042: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with C...
Source: This Week in Virology - MP3 Edition - September 9, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice
CONCLUSIONS: This is the first study to demonstrate that HMPV VLP was successfully prepared in the baculovirus expression system. HMPV VLP could induce specific humoral and cellular immune responses as well as protective efficacy, and aluminum hydroxide may be an effective adjuvant in mice.PMID:37657510 | DOI:10.1016/j.virusres.2023.199215
Source: Virus Research - September 1, 2023 Category: Virology Authors: Fenlian Ma Aijun Chen Lihong Yao Hanchun Gao Qian Zhang Wenzhe Hou Lishu Zheng Source Type: research
TWiV 1038: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and virological treatment failure, incidence of new-onset hypertension post–COVID-19: comparison with influenza, and post-acute sequel...
Source: This Week in Virology - MP3 Edition - August 26, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 1034: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment for COVID-19 impact short and long- term outcomes in a large generalizable population, persistent endothelial dysfunction in post-...
Source: This Week in Virology - MP3 Edition - August 12, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
T4 bacteriophage nanoparticles engineered through CRISPR provide a versatile platform for rapid development of flu mucosal vaccines
Antiviral Res. 2023 Jul 27:105688. doi: 10.1016/j.antiviral.2023.105688. Online ahead of print.ABSTRACTVaccines that trigger mucosal immune responses at the entry portals of pathogens are highly desired. Here, we showed that antigen-decorated nanoparticle generated through CRISPR engineering of T4 bacteriophage can serve as a universal platform for the rapid development of mucosal vaccines. Insertion of Flu viral M2e into phage T4 genome through fusion to Soc (Small Outer Capsid protein) generated a recombinant phage, and the Soc-M2e proteins self-assembled onto phage capsids to form 3M2e-T4 nanoparticles during propagatio...
Source: Antiviral Research - July 29, 2023 Category: Virology Authors: Mengling Li Cen Chen Xialin Wang Pengju Guo Helong Feng Xueqi Zhang Wanpo Zhang Changqin Gu Jingen Zhu Guoyuan Wen Yaoyu Feng Lihua Xiao Guiqing Peng Venigalla B Rao Pan Tao Source Type: research
Phylogenetic analysis and docking study of neuraminidase gene of influenza A/H1N1 viruses circulating in Iran from 2010 to 2019
This study highlighted the evolutionary trend of influenza A virus/H1N1 circulating in Iran, which provides a preliminary viewpoint for a better comprehension of new emerging strains' virulence and thus, more appropriate monitoring of influenza virus A/H1N1 during each outbreak season.PMID:37490957 | DOI:10.1016/j.virusres.2023.199182
Source: Virus Research - July 25, 2023 Category: Virology Authors: Sina Moeini Atefeh Mohebbi Behrokh Farahmand Parvaneh Mehrbod Fatemeh Fotouhi Source Type: research
Identification of alpha-linolenic acid as a broad-spectrum antiviral against zika, dengue, herpes simplex, influenza virus and SARS-CoV-2 infection
Antiviral Res. 2023 Jul 8:105666. doi: 10.1016/j.antiviral.2023.105666. Online ahead of print.ABSTRACTZika virus (ZIKV) has garnered global attention due to its association with severe congenital defects including microcephaly. However, there are no licensed vaccines or drugs against ZIKV infection. Pregnant women have the greatest need for treatment, making drug safety crucial. Alpha-linolenic acid (ALA), a polyunsaturated ω-3 fatty acid, has been used as a health-care product and dietary supplement due to its potential medicinal properties. Here, we demonstrated that ALA inhibits ZIKV infection in cells without loss of ...
Source: Antiviral Research - July 10, 2023 Category: Virology Authors: Yifei Feng Yan Yang Shuting Zou Shuqi Qiu Hao Yang Yi Hu Guifen Lin Xingang Yao Shuwen Liu Min Zou Source Type: research
TWiV 1016: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with extended duration Nirmatrelvir/Ritonavir, anemia as a risk factor for disease progression in patients admitted for COVID-19, impact of...
Source: This Week in Virology - MP3 Edition - June 17, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study
Antiviral Res. 2023 Jun 1:105639. doi: 10.1016/j.antiviral.2023.105639. Online ahead of print.ABSTRACTVaccination remains the best prevention strategy against influenza. The MDCK-based influenza vaccine prompted the development of innovative cell culture manufacturing processes. In the present study, we report the effects of multiple administrations of a candidate, seasonal, MDCK-based, quadrivalent split influenza virus vaccine MDCK-QIV in Sprague-Dawley (SD) rats. Moreover, the effects of the vaccine were evaluated in terms of fertility and early embryonic development, embryo-fetal development, and perinatal toxicity in ...
Source: Antiviral Research - June 3, 2023 Category: Virology Authors: Jiayou Zhang Xuanxuan Nian Bo Liu Zhegang Zhang Wei Zhao Xixin Han Yumei Ma Dongwu Jin Hua Ma Qingmei Zhang Ran Qiu Fang Li Zheng Gong Xuedan Li Ying Yang Yichao Tian Li Zhou Kai Duan Xinguo Li Zhongren Ma Xiaoming Yang Source Type: research
