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Total 111 results found since Jan 2013.

Low handgrip strength is associated with diabetic foot disease in geriatric patients with type 2 diabetes
This study aims to reveal the prevalence of low handgrip strength in older patients with type 2 diabetes who have diabetic foot disease and to assess the association of handgrip strength with diabetic foot disease in older patients with type 2 diabetes.METHODS: Eighty-nine geriatric patients with diabetic foot ulcers and 69 patients without diabetic foot ulcers who presented to the endocrinology outpatient clinic between August 2020 and November 2021 were included in the study. The exclusion criteria were the usage of steroids, stroke-induced quadriplegia, myopathy, disability, hemodialysis treatment, type 1 diabetes, pati...
Source: Turkish Journal of Medical Sciences - March 22, 2023 Category: General Medicine Authors: Eren İmre Ne şe Koçakgöl Erdi İmre Source Type: research

The role of potassium in muscle membrane dysfunction in end-stage renal disease
CONCLUSIONS: In ESRD patients, the muscle membrane is depolarized, mainly due to hyperkalemia.SIGNIFICANCE: Since normal muscle fatigue has been attributed to potassium-induced depolarization, it seems likely that this mechanism is also a major cause of the exaggerated muscle fatigue and weakness in ESRD patients.PMID:34740043 | DOI:10.1016/j.clinph.2021.09.012
Source: Clinical Neurophysiology - November 5, 2021 Category: Neurology Authors: Lotte Hardbo Larsen Werner J Z'Graggen Hugh Bostock S Veronica Tan Niels Henrik Buus Hatice Tankisi Source Type: research

Novel Asp511Thr mutation in McArdle disease with acute kidney injury caused by rhabdomyolysis
We present the case of a patient with long-term idiopathic hyperCKemia who, after contracting an upper respiratory tract infection, developed severe rhabdomyolysis and acute kidney injury. Upon hemodialysis, his renal function recovered and CK levels fell to below baseline, and maintenance therapy with vitamin B6 was also started. A molecular diagnosis of McArdle disease was subsequently made. Whole-exome sequencing revealed homozygous c1538delG (p.Asp511Thr fs*28) mutations in the PYGM gene, which was a novel mutation. Therefore, when investigating idiopathic hyperCKemia, glycogen storage disorders should also be considered.
Source: CEN Case Reports - March 20, 2019 Category: Urology & Nephrology Source Type: research

Late ‐onset Pompe's disease in a hemodialysis patient: A first case report
Abstract A 37‐year‐old hemodialysis patient appeared with unusual somnolence during 2 successive hemodialysis sessions. Blood gas analysis revealed hypercapnic respiratory failure and spirometry restrictive lung disease. After exclusion of other causes of restrictive lung disease with chest CT‐scan and cerebrum MRI, electrophysiological study revealed myopathy. Because besides lordosis and limb‐girdle gait the patient was ambulant the possibility of late‐onset Pompe's disease was set and confirmed with evaluation of α‐glucosidase activity and genetic analysis. Enzyme replacement therapy (ERT) with aglucosidase...
Source: Hemodialysis International - October 3, 2017 Category: Hematology Authors: Theodoros Eleftheriadis, Panagiota Makri, Paschalia Karakosta, Georgios Pissas, Vassilios Liakopoulos, Helen Michelakakis, Georgios M. Hadjigeorgiou, Ioannis Stefanidis Tags: Case Report Source Type: research