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Procedure: Ultrasound

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Total 104 results found since Jan 2013.

Imaging: seeing muscle in new ways
Purpose of reviewThe idiopathic inflammatory myopathies are diseases that can be difficult to diagnose and evaluate, but diagnosis has been improved by modern imaging techniques. Advances in imaging continue to be made. Therefore, it is necessary to evaluate the implications of these advances for the diagnosis, understanding, and management of muscle diseases. Recent findingsThere have been advances in imaging across multiple modalities. Several new radiotracers show an improved ability to focus on inflammation better than older agents. Magnetic resonance spectroscopy has shown the ability to diagnose several idiopathic in...
Source: Current Opinion in Rheumatology - October 2, 2014 Category: Rheumatology Tags: MYOSITIS AND MYOPATHIES: Edited by Paul H. Plotz Source Type: research

T.p.48
Acoustic Radiation Force Impulse (ARFI)-Imaging is a non-invasive ultrasound-based operator independent elastography method that assesses tissue stiffness. ARFI mechanically excites tissues with localized impulsive radiation resulting in shear wave propagation (m/s) away from the region of excitation. Shear wave velocity (SWV) increases when tissue is stiffer, and in muscle disorders, this may be related to either fibrosis or edema. Here we address the sensitivity and specificity of ARFI-imaging to changes in the individual muscles of patients with collagen 6 myopathy (COL6) and LAMA2 related muscular dystrophy (LAMA2), as...
Source: Neuromuscular Disorders - October 1, 2014 Category: Neurology Authors: , C. Vuillerot, D. Nguyen, K. Yang, S. Auh, S. Donkervoort, K. Meilleur, M. Leach, M. Jain, A. Rutkowski, C. Bönnemann Source Type: research

T.P.48: Acoustic radiation force impulse imaging for the longitudinal assessment of muscle tissue stiffness in collagen 6 myopathy and LAMA2 related muscular dystrophy
Acoustic Radiation Force Impulse (ARFI)-Imaging is a non-invasive ultrasound-based operator independent elastography method that assesses tissue stiffness. ARFI mechanically excites tissues with localized impulsive radiation resulting in shear wave propagation (m/s) away from the region of excitation. Shear wave velocity (SWV) increases when tissue is stiffer, and in muscle disorders, this may be related to either fibrosis or edema. Here we address the sensitivity and specificity of ARFI-imaging to changes in the individual muscles of patients with collagen 6 myopathy (COL6) and LAMA2 related muscular dystrophy (LAMA2), as...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: J. Dastgir, C. Vuillerot, D. Nguyen, K. Yang, S. Auh, S. Donkervoort, K. Meilleur, M. Leach, M. Jain, A. Rutkowski, C. Bönnemann Source Type: research

G.P.39: An international prospective, longitudinal study of the natural history and functional status of patients with myotubular myopathy
We present here a prospective study of the pathophysiology of XLMTM to characterize the disease course by using standardized evaluations. A total of 60 patients with XLMTM, male or symptomatic female of any age, are planned to be enrolled in North America and Europe. Visit frequency and assessments are adjusted to age, ambulatory and respiratory status. Evaluations include standard liver ultrasound, clinical exam, ophthalmoplegia assessment, pulmonary function tests, strength and motor function assessment by using upper limb-specific devices and common scales, six-minute walk test, activity monitoring using the Actimyo dev...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: M. Annoussamy, H. Landy, D. Ramsdell, M. Nelken, F. Muntoni, C. Bönnemann, D. Bharucha, J.J. Dowling, K. Amburgey, C. Lilien, G. Ollivier, J. Laporte, V. Biancalana, U. Schara, J.M. Cuisset, A. D’Amico, N. Deconinck, P.Y. Jeannet, A. Klein, J. Fluss, M Source Type: research

Ultrasound assessment of the diaphragm: Preliminary study of a canine model of x‐linked myotubular myopathy
Discussion: This pilot demonstrates the feasibility of using ultrasound for quantitative assessment of the diaphragm in a canine model. Ultrasonography may potentially replace invasive measures of diaphragm function in canine models and in humans in the future, for non‐invasive respiratory monitoring and evaluation of neuromuscular disease. © 2014 Wiley Periodicals, Inc.
Source: Muscle and Nerve - May 23, 2014 Category: Internal Medicine Authors: Aarti Sarwal, Michael S. Cartwright, Francis O. Walker, Erin Mitchell, Anna Buj‐Bello, Alan H. Beggs, Martin K. Childers Tags: Short Report Source Type: research

Pompe Disease: Distal Myopathy In A Previously Unreported Heterozygous Variant (P3.297)
Conclusion: Our patients present the phenotypic heterogeneity of PD under the same genotypic variation in the same family, being ours the first distal myopathy case reported. We also detected a previously unreported heterozygous variant in exon 8 of the GAA gene (c.1198G>A p.V400I). PD is a rare, heterogeneous condition that may mimic many neuromuscular conditions.Disclosure: Dr. Farinhas has nothing to disclose. Dr. Nascimento has nothing to disclose. Dr. Davidovich has nothing to disclose. Dr. Dornas has nothing to disclose. Dr. Pupe has nothing to disclose. Dr. Coutinho has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dib, J., Nascimento, O., Davidovich, E., Dornas, R., Pupe, C., Coutinho, B. Tags: Muscle Disease Source Type: research

Using the Coronary Artery Calcium Score to Guide Statin Therapy: A Cost-Effectiveness Analysis Original Articles
Conclusions— CAC testing in intermediate risk patients can be cost-effective but only if statins are costly or significantly affect quality of life.
Source: Circulation: Cardiovascular Quality and Outcomes - March 18, 2014 Category: Cardiology Authors: Pletcher, M. J., Pignone, M., Earnshaw, S., McDade, C., Phillips, K. A., Auer, R., Zablotska, L., Greenland, P. Tags: Health policy and outcome research, Primary prevention, Coronary imaging: angiography/ultrasound/Doppler/CC, Epidemiology Original Articles Source Type: research

The clinical features, diagnosis and classification of dermatomyositis.
Abstract Dermatomyositis (DM) is an idiopathic inflammatory myopathy (IIM) characterized by an inflammatory infiltrate primarily affecting the skeletal muscle and skin. Most common and peculiar cutaneous lesions include Gottron's papules, Gottron's sign and heliotrope rash. Different DM subsets have been identified until now encompassing classic DM, amyopathic DM, hypomyopathic DM, post-myopathic DM, and DM sine dermatitis. Patients with DM have a higher incidence rate of malignancy than the normal population. In these patients cancer occurs in about 30% of cases with higher occurrence in men and in elderly people...
Source: Journal of Autoimmunity - January 24, 2014 Category: Allergy & Immunology Authors: Iaccarino L, Ghirardello A, Bettio S, Zen M, Gatto M, Punzi L, Doria A Tags: J Autoimmun Source Type: research

P.13.9 Acoustic radiation force impulse imaging for the differentiation of muscle tissue stiffness in neuromuscular disorders
Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. It involves the mechanical excitation of tissue using acoustic pulses to generate localized displacements resulting in shear-wave propagation, which is tracked using correlation-based methods and recorded in meters/s. The aim of this study is to evaluate the sensitivity and specificity of ARFI-imaging for muscle tissue stiffness differentiation (fat vs. fibrous tissue) in select muscles of patients unaffected by muscle disease vs. those affected by collagen 6 myopathy (COL6), LAM...
Source: Neuromuscular Disorders - September 16, 2013 Category: Neurology Authors: J. Dastgir, C. Vuillerot, K. Harrison, A. Poon, S. Donkervoort, M. Leach, M. Jain, K. Meilleur, A. Rutkowski, A. Mankodi, C. Bonnemann Source Type: research

The role of ultrasound in fetal congenital myopathy detection: a novel case of fetal‐onset cap myopathy
What's already known about this topic?Rare heterogeneous group of neuromuscular disorders.Associated with severe, often fatal phenotypes – Prenatal parental counselling and ‘high risk screening’ importantPrenatal diagnosis primarily reliant upon ultrasound detection What does this study add?Introduces a novel, lethal fetal form of cap myopathy.Evaluates range of ultrasound features and how detection can be facilitatedRe‐confirms fetal‐onset CM represents important, complex diagnostic challenge.
Source: Prenatal Diagnosis - June 1, 2013 Category: Perinatology & Neonatology Authors: J. A. Tamblyn, R. K. Morris, P. Cox, B. Hargitai, M. D. Kilby Tags: Research Letter Source Type: research

Severe congenital RYR1-associated myopathy: The expanding clinicopathologic and genetic spectrum
Conclusions: This series confirms and expands the clinical and histologic variability associated with severe congenital RYR1-associated myopathy. Both dominant and recessive mutations of the RYR1 gene can result in a severe neonatal-onset phenotype, but more clinical and histologic heterogeneity has been seen in those with recessive RYR1 gene mutations. Central cores are not obligatory histologic features in recessive RYR1 mutations. Sparing of the rectus femoris muscle on imaging should prompt evaluation for RYR1-associated myopathy in the appropriate clinical context.
Source: Neurology - April 22, 2013 Category: Neurology Authors: Bharucha-Goebel, D. X., Santi, M., Medne, L., Zukosky, K., Dastgir, J., Shieh, P. B., Winder, T., Tennekoon, G., Finkel, R. S., Dowling, J. J., Monnier, N., Bonnemann, C. G. Tags: Ultrasound, Muscle disease, All Pediatric, All Genetics ARTICLE Source Type: research

Novel SNP array analysis and exome sequencing detect a homozygous exon 7 deletion of MEGF10 causing early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD)
Abstract: Early-onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) is a myopathic disorder associated with mutations in MEGF10. By novel analysis of SNP array hybridization and exome sequence coverage, we diagnosed a 10-years old girl with EMARDD following identification of a novel homozygous deletion of exon 7 in MEGF10. In contrast to previously reported EMARDD patients, her weakness was more prominent proximally than distally, and involved her legs more than her arms. MRI of her pelvis and thighs showed muscle atrophy and fatty replacement. Ultrasound of several muscle groups revealed dense homogenou...
Source: Neuromuscular Disorders - March 4, 2013 Category: Neurology Authors: Tyler Mark Pierson, Thomas Markello, John Accardi, Lynne Wolfe, David Adams, Murat Sincan, Noor M. Tarazi, Karin Fuentes Fajardo, Praveen F. Cherukuri, Ilda Bajraktari, Katy G. Meilleur, Sandra Donkervoort, Mina Jain, Ying Hu, Tanya J. Lehky, Pedro Cruz, Tags: Research papers Source Type: research

A Novel Method for Targeting Intramuscular Diaphragm Injections Using Ultrasound and Electromyography (P02.220)
CONCLUSIONS: This study demonstrates the feasibility and practicality of using ultrasound to guide injections and needle EMG in animal models in an effort to reduce complications associated with conventional blind technique. Further, this new method demonstrates the feasibility of targeted diaphragm injections with gene replacement therapy in muscle diseases.Supported by: MDA (Muscular Dystrophy Association); AFM (Association Francais Contre les Myopathy); Joshua Frase Foundation.Disclosure: Dr. Sarwal has nothing to disclose. Dr. Serfas has nothing to disclose. Dr. Mitchell has nothing to disclose. Dr. Cartwright has noth...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sarwal, A., Serfas, J. D., Mitchell, E., Cartwright, M., Beggs, A., Buj-Bello, A., Childers, M. Tags: P02 Clinical Neurophysiology: EMG Source Type: research